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Insulin Internalization as Studied by Subcellular Fractionation and Electron-Microscopic Radioautography

  • J. J. M. Bergeron
  • Masood N. Khan
  • Barry I. Posner
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

The techniques of subcellular fractionation and e.m. radioautography have defined novel intracellular components which participate in receptor-mediated endocytosis [1, 2]. These components have been interpreted as vesicles accumulating within the trans* Golgi apparatus (G.a.). The vesicles are highly enriched in receptors for insulin and prolactin; during receptor-mediated insulin internalization the vesicles concentrate reasonably intact insulin prior to donation of hormone to a catabolic compartment (probably the secondary lysosome).

Keywords

Latent Image Vesicular Structure Secondary Lysosome Lysosomal Fraction Senior Editor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. J. M. Bergeron
    • 1
  • Masood N. Khan
    • 1
  • Barry I. Posner
    • 1
  1. 1.Departments of Anatomy and MedicineMcGill UniversityMontrealCanada

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