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Architecture of Plasma Membrane Hormone Receptor-Effector Systems

  • Harry LeVineIII
  • Naji E. Sahyoun
  • Pedro Cuatrecasas
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

The hormonally responsive adenylate cyclase system is an example of a system subject to complex regulation that undergoes shifts in equilibria of binding of components to one another and to elements of the cytoskeleton. In these and other interactions such as those with specific membrane lipids, cytosolic macromolecules, and metabolites, adenylate cyclase undergoes reversible changes in catalytic activity. The associative and dissociative processes involved are discussed briefly along with the methodology implicit in such studies. Techniques utilized in these studies may allow differential elution of components of the receptor-effector system.

Keywords

Adenylate Cyclase Membrane Structure Integral Membrane Protein Macromolecular Complex Cytoskeletal Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Harry LeVineIII
    • 1
  • Naji E. Sahyoun
    • 1
  • Pedro Cuatrecasas
    • 1
  1. 1.Wellcome Research LaboratoriesDepartment of Molecular BiologyResearch Triangle ParkUSA

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