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Hormone Receptor — Adenylate Cyclase Interaction: Superpotency, Superaffinity and Desensitization Phenomena

  • Dennis Schulster
  • Michael D. Salmon
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 13)

Abstract

(1) Cell fusion studies have shown that β-adrenergic receptors concerned in adenylate cyclase (AC) activation can move from one cell to another. (2) If agonists such as protein hormones are joined to a large rigid carrier molecule such as a virus, they may exhibit superpotency that reflects superaffinity. (3) Catecholamine desensitization as studied with turkey erythrocytes is due to a regulatory defect at the level of nucleotide regulatory proteins (Ns -protein J. In general this article concerns some interactions of the hormone receptor-N-protein -AC complex.

Keywords

Adenylate Cyclase Tobacco Mosaic Virus Human Erythrocyte Sendai Virus Hormone Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Dennis Schulster
    • 1
  • Michael D. Salmon
    • 1
  1. 1.Hormones Division, National Institute for Biological Standards and ControlHampstead, LondonUK

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