Permeability and Immunohistochemical Studies of Brain in Chronic Hypertension

  • Sukriti Nag
  • David M. Robertson
  • Henry B. Dinsdale


A common finding in humans with chronic hypertension is the presence of multifocal areas of old necrosis located in the basal ganglia region and the cerebral cortex principally in the boundary zones between the 3 major cerebral arteries16,4. Similar lesions have been observed in the various models of chronic hypertension developed to study the human disease2,15,13. The pathogenesis of these lesions generally referred to as microinfarcts is uncertain. Suggested mechanisms include vascular occlusion4 and spasm of penetrating arterioles2.


Evans Blue Chronic Hypertension Cortical Lesion Hypertensive Animal Permeability Alteration 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Sukriti Nag
    • 1
  • David M. Robertson
    • 1
  • Henry B. Dinsdale
    • 2
  1. 1.Departments of PathologyQueens’ University and Kingston General Hospital KingstonOntarioCanada
  2. 2.Departments of MedicineQueens’ University and Kingston General Hospital KingstonOntarioCanada

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