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Suppression of Brain Swelling with Mannitol and Perfluorochemicals: an Experimental Study

  • J. Suzuki
  • T. Kayama
  • T. Yoshimoto
  • H. Seki

Abstract

Prevention of the early pathological changes in brain tissue following acute cerebral infarction would be extremely helpful. Previously, we have reported a number of studies concerning the beneficial effect of mannitol in cerebral ischemia1,3,5,7. Recently, our attention has been attracted by oxygen carriers, the perfluorochemicals (FC) which — due to their molecular size can be transported into small blood vessels. We have studied the effect of these compounds on brain infarction in comparison with mannitol. For that purpose, an experimental model of ischemic brain swelling in dogs was used suitable, for the study of drugs in cerebral ischemia.

Keywords

Cerebral Infarction Ischemic Brain Brain Edema Vascular Occlusion Evans Blue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • J. Suzuki
    • 1
  • T. Kayama
    • 1
  • T. Yoshimoto
    • 1
  • H. Seki
    • 1
  1. 1.Division of Neurosurgery, Institute of Brain DiseasesTohoku University, School of MedicineSendaiJapan

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