Pharmacological Approach to Postischemic Brain Edema in Gerbils

  • B. B. Mršulja
  • B. M. Djuričić
  • Vesna Cvejić
  • D. V. Mićić


Biochemical research on cerebral edema together with the different pharmacological approaches to influence this condition have demonstrated an enormous complexity2,8,9,11. A number of extensive biochemical studies, including those of ourselves have focussed on the role of Na+-K+-ATPase, cyclic AMP, and brain edema factors, such as serotonin (5-HT), or prostaglandins (PGs)5,8,9,10. It is known that reestablishment of cerebral blood flow after circulatory arrest by release of arterial occlusion in the gerbil markedly enhances the formation of ischemic brain edema, rendering the model suitable to approach biochemically and pharmacologically the edema in progress. The data obtained from this model are not confused by external factors, as in other models. The high rate of survival of animals subjected to short-term ischemia by bilateral occlusion of the common carotid arteries for 15 min is another asset of the model. In this report, the relationship between 5-HT metabolism and cerebral water content was analyzed during the reflow period after transient ischemia. 5-HT metabolism of the brain was influenced during early postischemia by drugs which are known to affect amine synthesis and degradation, and which interact with pre- and postsynaptic 5-HT receptors.


Common Carotid Artery Brain Edema Circulatory Arrest Pharmacological Approach Serotonin Turnover 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • B. B. Mršulja
    • 1
  • B. M. Djuričić
    • 1
  • Vesna Cvejić
    • 1
  • D. V. Mićić
    • 1
  1. 1.CVD Research Group, Institute of BiochemistrySchool of MedicineYugoslavia

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