Racemic (d,1) and d-ISOMER Propranolol in Focal Cerebral Ischemia

  • John P. LatchawJr.
  • John R. Little
  • Robert M. Slugg
  • Ronald R. Lesser
  • Nicholas T. Stowe


Propranolol has been found to have a protective effect in experimental myocardial and renal ischemia22,28,27,8,29,14,12. Propranolol has been found to reduce regional cerebral blood flow (rCBF) in non-ischemic cats6. Since many stroke-prone patients receive this medication, this finding may present serious implications in cerebral ischemia. The objective of the present investigation was to study the effects of racemic (d,1) propranolol and its weak beta-blocking isomer, d-propranolol, upon rCBF and morphological changes in experimental acute focal cerebral ischemia.


Cerebral Ischemia Middle Cerebral Artery Occlusion Focal Cerebral Ischemia Regional Cerebral Blood Flow Evans Blue 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John P. LatchawJr.
    • 1
  • John R. Little
    • 1
  • Robert M. Slugg
    • 1
  • Ronald R. Lesser
    • 2
  • Nicholas T. Stowe
    • 3
  1. 1.Department of NeurosurgeryClevelandUSA
  2. 2.Department of NeurologyClevelandUSA
  3. 3.Department of UrologyClevelandUSA

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