Treatment of Experimental Acute Lead Encephalopathy

  • Raymond A. Clasen
  • Sylvia Pandolfi
  • Thomas J. Hoeppner
  • Jaclynn R. Clasen


The current recommendations for therapy in acute lead encepha-lopathy are the immediate use of calcium disodium ethylenediamine-tetraacetate (EDTA) and dimercaptopropanol (BAL) in combination1. These chelating agents bind and inactivate lead ions. The complex is then rapidly excreted by the kidney. Also recommended to reduce the accompanying cerebral edema are restrictions of fluids and the judicious use of mannitol. To our knowledge it has not been objectively demonstrated that intravenous hypertonic solutions do indeed reduce the edema of lead encephalopathy, but clinical improvement of patients, so treated, has been reported12. The use of steroids has also been reported on clinical grounds as being both effective10 and ineffective13.


Cerebral Edema Vasogenic Edema Edema Fluid Invert Sugar Calcium Disodium 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Raymond A. Clasen
    • 1
  • Sylvia Pandolfi
    • 1
  • Thomas J. Hoeppner
    • 1
  • Jaclynn R. Clasen
    • 1
  1. 1.Departments of Pathology and NeurologyLuke’s Medical CenterChicagoJapan

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