The Effect of Indomethacin on Cortical Specific Gravity During Regional Ischemia and Recirculation
Accumulation of free fatty acids (FFAs) and subsequent per-oxidation has been shown during cerebral ischemia followed by re-circulation20. It has been suggested that autooxidation of free fatty acids (free radical reactions) and enzymatic peroxidation of fatty acids (arachidonate cascade) are involved in ischemic brain damage. Gaudet et al5 have shown an increase of prostaglandin synthesis in cerebral tissue of Mongolian gerbils following ischemia. However, the extent of brain edema and the prostaglandin levels did not correlate, six hours after unilateral carotid occlusion. Peroxidation of free fatty acids is considered maximal at the beginning of tissue reoxygenation after initiation of recirculation6. Therefore, the role of this process on development of brain damage should more clearly be studied by a recirculation model. The effect of indomethacin on postischemic cerebral perfusion has been investigated by Hallenbeck et al7. In the present study, the role of the arachidonate cascade in ischemic brain edema was analyzed by measurements of cortical specific gravity together with local cortical blood flow.
KeywordsMiddle Cerebral Artery Occlusion Brain Edema Brain Water Content Flow Depression Bilateral Common Carotid Artery Occlusion
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- 3.Demopoulos HB, Flamm ES, Seligman ML: Membrane perturbances in cerebral nervous system injury: Theoretical basis for free radical damage and a review of the experimental data. In Neural Trauma. Popp AJ et al (Eds) Raven Press, New York, 63–77 (1979).Google Scholar
- 4.Fridovich I: Hypoxia and oxygen toxicity. In: Cerebral hypoxia and its consequences. Fahn S, Davis JN, Rowland LP (Eds) Raven Press, New York. Adv Neurol 26: 255–259 (1979).Google Scholar
- 13.Nelson SR, Mantz ML, Maxwell H: Use of specific gravity in the measurement of brain edema. J Appl Physiol 30: 267–271 (1971).Google Scholar
- 18.Tamura A, Asano T, Tak Y, Manaka S, Hirakawa K, Sano K: Measurement of cerebral blood flow with hydrogen clearance method. Technique and a comparatively study with the venous outflow method. Brain Nerve (Tokyo) 30: 47–54 (1978).Google Scholar