Comparison Between Histology and Forebrain Water Content at Different Times after Cold Lesion

  • David Ashton
  • Jos van Reempts
  • Albert Wauquier


The differentiation of two basically different forms of brain edema, vasogenic and cytotoxic11 is now generally accepted. In vasogenic edema the main event is vascular damage, which results in an increased cerebrovascular permeability allowing escape of serum constituents into the surrounding extracellular space5. The driving force for the extravasation is the capillary transmural pressure gradient, which depends on the systemic arterial pressure11,13. Vasogenic cerebral edema has been considered to be the most frequent type of edema, since it accompanies all focal lesions of the brain, such as tumors, hematomas, injuries and infectious lesions, and some stages of cerebral ischemia .


Brain Edema Edema Formation Vasogenic Edema Pyknotic Nucleus Vibratome Section 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • David Ashton
    • 1
  • Jos van Reempts
    • 1
  • Albert Wauquier
    • 1
  1. 1.Depts. of Neuropharmacology and Cell BiologyJanssen Pharmaceutica Research LaboratoriesBeerseBelgium

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