Comparison Between Histology and Forebrain Water Content at Different Times after Cold Lesion
The differentiation of two basically different forms of brain edema, vasogenic and cytotoxic11 is now generally accepted. In vasogenic edema the main event is vascular damage, which results in an increased cerebrovascular permeability allowing escape of serum constituents into the surrounding extracellular space5. The driving force for the extravasation is the capillary transmural pressure gradient, which depends on the systemic arterial pressure11,13. Vasogenic cerebral edema has been considered to be the most frequent type of edema, since it accompanies all focal lesions of the brain, such as tumors, hematomas, injuries and infectious lesions, and some stages of cerebral ischemia .
KeywordsBrain Edema Edema Formation Vasogenic Edema Pyknotic Nucleus Vibratome Section
Unable to display preview. Download preview PDF.
- 1.Ashton D, Van Reempts J, Wauquier A: Behavioural, electroen-cephalographic and histological study of the protective effect of etomidate against histotoxic dysoxia produced by cyanide. Arch Int Pharmacodyn Ther 254: 196–213 (1981).Google Scholar
- 5.Clasen RA, Sky-Peck H, Pandolfi S, Laing I, Hass G: The chemistry of isolated edema fluid in experimental cerebral injury. In Brain Edema, Klatzo I, Seitelberger F (eds) Springer Verlag New York, 536–553 (1976).Google Scholar
- 6.Elliott KAC, Jasper H: Measurement of experimentally induced brain swelling and shrinkage. Am J Physiol 157: 122–129 (1949).Google Scholar
- 7.Go KG: The classification of brain edema. In Brain Edema, de Vlieger M, de Lange SA, Beks JWF. Wiley New York 3–9 (1981).Google Scholar
- 9.Hochwald GM, Camins MB: Perspectives on experimental and clinical cerebral edema. In Brain Edema, de Vlieger M, de Lange SA, Beks JWF (eds) John Wiley, New York 19–30 (1981).Google Scholar
- 18.Van Reempts J, Haseldonckx M, Borgers M: A simple technique for the macroscopic study of microvascular geometry and tissue perfusion, allowing simultaneous histopathologic evaluation. Microvasc Res submitted (1982).Google Scholar
- 19.Wauquier A, Ashton D, Clincke G, Niemegeers CJE: Anti-hypoxic effects of etomidate, thiopental and methohexital. Arch Int Pharmacodyn Ther 249: 330–334 (1981).Google Scholar