Experience with High-Dose, Alternate Day Methylprednisolone in Patients with Grade III/IV Astrocytoma and Secondary Cerebral Tumors
Corticosteroids are frequently used as adjuncts in the treatment of patients with malignant brain tumors. Treatment regimes widely differ, especially with respect to corticosteroids. The use of these drugs is influenced by the known side-effects of prolonged administration which include Cushing’s syndrome, sepsis, gastrointestinal hemorrhage, the precipitation of diabetes and myopathy. In patients with malignant or inoperable brain tumors, the potential advantages of corticosteroids in the short term are likely to outweigh their possible disadvantages in the long term since the overall prognosis for malignant brain tumors is so bad. So which corticosteroid should we use, what dosage schedule and for how long?
KeywordsBrain Tumor Chronic Lymphocytic Leukemia Primary Brain Tumor Malignant Brain Tumor Steroid Regime
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