Experience with High-Dose, Alternate Day Methylprednisolone in Patients with Grade III/IV Astrocytoma and Secondary Cerebral Tumors

  • Rudy Capildeo
  • F. Clifford Rose


Corticosteroids are frequently used as adjuncts in the treatment of patients with malignant brain tumors. Treatment regimes widely differ, especially with respect to corticosteroids. The use of these drugs is influenced by the known side-effects of prolonged administration which include Cushing’s syndrome, sepsis, gastrointestinal hemorrhage, the precipitation of diabetes and myopathy. In patients with malignant or inoperable brain tumors, the potential advantages of corticosteroids in the short term are likely to outweigh their possible disadvantages in the long term since the overall prognosis for malignant brain tumors is so bad. So which corticosteroid should we use, what dosage schedule and for how long?


Brain Tumor Chronic Lymphocytic Leukemia Primary Brain Tumor Malignant Brain Tumor Steroid Regime 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Axelrod L: Glucocorticoid therapy. Medicine, 55: 39–65 (1976).CrossRefGoogle Scholar
  2. 2.
    Harter JG: Corticosteroids, their psychologie use in allergic disease. New York State Journal of Medicine. 66: 827–40 (1966).Google Scholar
  3. 3.
    Karnofsky DA, Burchenal JH: In: Evaluation of Chemotherapeutic agents. MacLoed CM, Ed. Publ. Columbia Univ. Press. 191–205 (1949).Google Scholar
  4. 4.
    Lieberman A, LeBrun Y, Glass P, Goodgold A, Lux W, Wise A, Ransonoff J: Use of high dose corticosteroids in patients with inoperable brain tumors. Neurol Neurosurg Psychiat 40: 678–682 (1977).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Rudy Capildeo
    • 1
  • F. Clifford Rose
    • 1
  1. 1.Department of NeurologyCharing Cross HospitalLondonUK

Personalised recommendations