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Element Fluxes in Ischemic Brain Nuclei and Their Possible Relationship to Brain Edema as Studied by Energy Dispersive X-Ray Analysis

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Recent Progress in the Study and Therapy of Brain Edema

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Abstract

Cerebral edema resulting from cerebral ischemia continues to be one of the most frustrating and least understood problems of contemporary medicine. Not only is ischemia an important primary phenomenon, it is becoming increasingly recognized as an important secondary phenomenon in many forms of brain insult. Pharmacological agents utilized clinically to treat the condition have varying degrees of efficacy and in general represent only partial solutions to the problem. Numerous clinical and experimental investigations have been done in an attempt to pinpoint the mechanisms leading to edema but none has provided a definite cause-effect sequence. Although biochemical mechanisms have received much attention, we feel that inorganic ion homeostasis appears to be one of the essentials in preventing cerebral edema following ischemia. One of the essentials in unraveling the pathophysiology of ionic disturbances is a precise understanding of electrolyte distribution in the cells and regions of the brain before and after the onset of ischemia as well as after restitution of blood flow.

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Author information

Authors and Affiliations

  1. Division of Neurosurgery, University of California, San Diego, VA Hospital, California, 92161, USA

    R. J. Ignelzi

  2. Department of Dermatology, University of California, San Francisco, California, 94143, USA

    C. W. Mehard

Authors
  1. R. J. Ignelzi
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  2. C. W. Mehard
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  3. A. Srull
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Editor information

Editors and Affiliations

  1. University of Groningen, Groningen, The Netherlands

    K. G. Go

  2. Institute of Surgical Research Grosshadern Clinic H, University of Munich, Munich, Federal Republic of Germany

    A. Baethmann

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© 1984 Plenum Press, New York

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Ignelzi, R.J., Mehard, C.W., Srull, A. (1984). Element Fluxes in Ischemic Brain Nuclei and Their Possible Relationship to Brain Edema as Studied by Energy Dispersive X-Ray Analysis. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_54

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  • DOI: https://doi.org/10.1007/978-1-4684-4616-6_54

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4618-0

  • Online ISBN: 978-1-4684-4616-6

  • eBook Packages: Springer Book Archive

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