Element Fluxes in Ischemic Brain Nuclei and Their Possible Relationship to Brain Edema as Studied by Energy Dispersive X-Ray Analysis

  • R. J. Ignelzi
  • C. W. Mehard
  • A. Srull


Cerebral edema resulting from cerebral ischemia continues to be one of the most frustrating and least understood problems of contemporary medicine. Not only is ischemia an important primary phenomenon, it is becoming increasingly recognized as an important secondary phenomenon in many forms of brain insult. Pharmacological agents utilized clinically to treat the condition have varying degrees of efficacy and in general represent only partial solutions to the problem. Numerous clinical and experimental investigations have been done in an attempt to pinpoint the mechanisms leading to edema but none has provided a definite cause-effect sequence. Although biochemical mechanisms have received much attention, we feel that inorganic ion homeostasis appears to be one of the essentials in preventing cerebral edema following ischemia. One of the essentials in unraveling the pathophysiology of ionic disturbances is a precise understanding of electrolyte distribution in the cells and regions of the brain before and after the onset of ischemia as well as after restitution of blood flow.


Brain Edema Cerebral Edema Methyl Butane Element Flux Liquid Nitrogen Bath 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. J. Ignelzi
    • 1
  • C. W. Mehard
    • 2
  • A. Srull
  1. 1.Division of NeurosurgeryUniversity of CaliforniaSan DiegoUSA
  2. 2.Department of DermatologyUniversity of CaliforniaSan FranciscoUSA

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