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Protein Tracer Permeability of the Blood-Brain Barrier After Transient Cerebral Ischemia in Gerbils

  • K. G. Go
  • H. J. Houthoff
  • S. Huitema
  • M. Spatz

Abstract

Clamping of both common carotid arteries for 15 min in the Mongolian gerbil (Meriones unguiculatus) is a well-known model for the study of postischemic changes in the permeability of the blood-brain barrier (BBB) and in the formation of edema1,12,15. The two main characteristics of this model are the differential permeability changes of the BBB and a biphasic edema formation. The permeability of the BBB is increased for sucrose from the start onwards, while an increased permeability for 5-hydroxytryptamine, ∝-amino-isobutyric acid and norepineprhin as well as dextran occurs from 24, 36 and 72 and 144 postichemic hr onwards, respectively.

Keywords

Brain Edema Mongolian Gerbil Transient Cerebral Ischemia Meriones Unguiculatus Protein Tracer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • K. G. Go
    • 1
    • 2
  • H. J. Houthoff
    • 1
    • 2
  • S. Huitema
    • 1
    • 2
  • M. Spatz
    • 1
    • 2
  1. 1.Departments of Neurosurgery and PathologyUniversity Hospital and University of GroningenGroningenUSA
  2. 2.The Netherlands, and N.I.N.C.D.S.National Institutes of HealthBethesdaUSA

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