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A Model to Study Ischemic Brain Edema in Rats and the Influence of Drugs

  • Osamu Gotoh
  • Tohru Koide
  • Takao Asano
  • Kintomo Takakura
  • Akira Tamura
  • Keiji Sano

Abstract

We have recently reported that middle cerebral artery (MCA) occlusion in rats produces a uniform pattern of cerebral infarction13. Development of edema in this model was further studied using exogenous and endogenous protein tracers. It was found that vasogenic edema developed several hours after MCA occlusion3. The purpose of the present study was to find out whether progression of edema can be quantitatively evaluated in this model of focal cerebral ischemia. The effect of dexamethasone and of a nicotinamide derivative (AVS: 1,2-Bis(nicotinamido)propane) in the time-course of edema were studied in addition. The therapeutic effect of steroids on ischemic brain edema is still a controversial subject. AVS is a scavenger of hydroxyl radicals (OH). Since involvement of free radicals is considered in ischemic brain edema, treatment with AVS was compared with that of dexamethasone.

Keywords

Brain Edema Focal Cerebral Ischemia Systemic Arterial Pressure Brain Water Content Daily Increment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Osamu Gotoh
    • 1
  • Tohru Koide
    • 1
  • Takao Asano
    • 1
  • Kintomo Takakura
    • 1
  • Akira Tamura
    • 2
  • Keiji Sano
    • 2
  1. 1.Department of NeurosurgeryUniversity of Tokyo HospitalJapan
  2. 2.Department of NeurosurgeryTeikyo University HospitalJapan

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