Advertisement

Phasic Recognition of Edema Caused by Ischemia

  • B. M. Djuričić
  • D. V. Mićić
  • B. B. Mršulja

Abstract

Brain edema is associated with an accumulation of water in brain tissue. Therefore, common mechanisms may exist with regard to the pathogenesis of disturbances of cell metabolism due to a restriction of blood supply and an impairment of osmoregulation. However, accumulation of water in brain tissue commences only — after ischemia, when circulation is reestablished8. Although there is little doubt that it is the ischemic insult which triggers the mechanisms of edema formation, the different factors involved in the proces of edema formation have not been precisely identified yet. On the other hand, the fact that many compounds and factors are suggested to be involved in the development of brain edema may indeed uncover our ignorance of the basic mechanisms of ischemic brain edema1,7. It is widely held, that development of energy failure secondary to the restriction of blood flow causes breakdown of ionic pumps resulting in an intracellular accumulation of Na+, and consequently of water, leading to cell swelling. However, this notion may be in conflict with the findings mentioned above on experimental stroke in gerbils that edema evolves during post-ischemic recirculation, i.e. when cerebral blood flow is already established again and the energy reserves restored6,7.

Keywords

ATPase Activity Brain Edema Edema Formation Brain Water Content Energy Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Baethmann A, Oettinger W, Rothenfusser W, Kempski O, Unterberg A, Geiger R: Brain edema factors: Current state with particular reference to plasma constituent and glutamate. In: Brain Edema, Cervos-Navarro J, Ferszt R (Eds.), Adv in Neurol 28: 171–196 (1980).Google Scholar
  2. 2.
    Bradford MM: A rapid and sensitive method for the quantitation of micrograms of protein utilizing the principle of protein dye-binding. Analyt Biochem 72: 248–254 (1976).CrossRefGoogle Scholar
  3. 3.
    Djuricic BM Mrsulja BB: Enzymic activity of the brain: micro-vessels vs. total forebrain homogenate. Brain Res 138: 561–564 (1977).CrossRefGoogle Scholar
  4. 4.
    Elliott KAC, Jasper H: Measurement of experimentally induced brain swelling and shrinkage. Am J Physiol 157: 122–126 (1949).Google Scholar
  5. 5.
    Lowry OH, Passonneau JV: A flexible system of enzymatic analysis. Academic Press, New York (1972).Google Scholar
  6. 6.
    Lust WD, Kobayashi M, Mrsulja BB, Wheaton A, Passonneau JV: Cyclic nucleotide levels in the gerbil cerebral cortex, cerebellum and spinal cord following bilateral ischemia. In: Tissue Hypoxia and Ischemia, Reivich M, Coburn R, Lahiri S, Chance B (Eds.) Plenum Press, New York, 287–298 (1977).CrossRefGoogle Scholar
  7. 7.
    Mršulja BB, Djuričić BM, Cvejić V, Mršulja BJ, Abe K, Spatz M, Klatzo I: Biochemistry of experimental ischemic brain edema. In: Brain Edema, Cervos-Navarro J, Ferszt R (Eds.) Adv Neurol 28: 217–230 (1980).Google Scholar
  8. 8.
    Mršulja BB, Mićić DV, Djuričić BM: Gerbil stroke model: an approach to the study of therapeutic aspects of postischemic brain edema. In: Stroke: Animals Models, Stefanovich V (Ed.) Pergamon Press, Oxford (in press) (1982).Google Scholar
  9. 9.
    Mršulja BB, Djuričić BM, Cvejić V, Mićić DV: Pharmacological approach to the postischemic brain edema in gerbils (this symposium) (1983).Google Scholar
  10. 10.
    Pappius HM, Dayes LA: Hypertonic urea. Its effect on the distribution of water and electrolytes in normal and edematous tissue. Arch Neurol 13: 395–401 (1965).CrossRefGoogle Scholar
  11. 11.
    Thorpe PJ: Propentophylline, drugs of the Future 7: 119–120 (1982).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • B. M. Djuričić
    • 1
  • D. V. Mićić
    • 1
  • B. B. Mršulja
    • 1
  1. 1.CVD Research Group, Institute of BiochemistrySchool of MedicineBelgradeYugoslavia

Personalised recommendations