Tissue Pressure in Ischemic Brain Edema

  • Fausto Iannotti
  • Julian T. Hoff


Very early after an ischemic insult to the brain, edema develops3. Ischemic edema, according to Klatzo, results from a combination of insults which develop sequentially. Initially, the Blood Brain Barrier (BBB) to macromolecules is not damaged and water accumulates in the intracellular compartment, which expands, while the extracellular space is reduced. Hours to days after the ischemic insult, vasogenic edema develops. If time influences the evolution of edema, then the decrease in cerebral blood flow (CBF) triggers its formation. A disturbance of water homeostasis with cellular swelling, seems to occur in the baboon3 and gerbil2 cortex when rCBF falls below 19–20 ml/100 g/min. When the decrease in flow is more severe, more water accumulates in the brain tissue . From this perspective we regard edema as an expression of the ischemic damage. However, as suggested by Hossmann and Schuier , when edema forms in an ischemic area the damage becomes progressive and rCBF falls further as edema develops.


Cerebral Blood Flow Middle Cerebral Artery Occlusion Brain Edema Ischemic Insult Vasogenic Edema 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Fausto Iannotti
    • 1
  • Julian T. Hoff
    • 1
  1. 1.Section of NeurosurgeryUniversity of Michigan AnnArborUSA

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