Brain Edema Following Focal Cerebral Ischemia in the Rat
The small-animal model of focal cerebral ischemia produced by occluding a middle cerebral (MCA) of the rat has already proved useful in the studies of pathophysiology of this type of cerebro-vascular disease12,13. Even though there are several other models of cerebral ischemia in small animals, such as mongolian gerbils or rats, occlusion of the middle cerebral artery has the advantage of producing focal incomplete ischemia, such as is most commonly encountered in human stroke. Because of the reproducibility of the MCA occlusion model (in respect of the distribution of irreversible ischemic cell changes and the topography and magnitude of alterations in local cerebral blood flow) this experimental approach is particularly suited for investigations with the range of autoradio-graphic techniques, now available to assess blood-brain barrier (BBB) permeability and local cerebral blood flow (CBF).
KeywordsSpecific Gravity Middle Cerebral Artery Occlusion Caudate Nucleus Brain Edema Focal Cerebral Ischemia
Unable to display preview. Download preview PDF.
- 4.Iannotti F, Hoff JT, Crockard A: Does reperfusion improve ischemic edema? J Cereb Blood Flow Metabol 1 (Suppl. 1): S168–169 (1981).Google Scholar
- 6.Sakurada O, Kennedy C, Jehle JW, Brown JD, Carbin GL, Sokoloff L: Measurement of local cerebral blood flow with iodo 14C anti-pyrine. Am J Physiol 234: H59–H66 (1978).Google Scholar
- 8.Shigeno T, Brock M, Shigeno S, Fritschka E, Cervos-Navarro J: The determination of brain water content: microgravimetry versus drying-weighing method. J Neurosurg (in press).Google Scholar
- 9.Shigeno T, Fritschka M, Brock M, Shigeno S: Ischemic brain edema: cytotoxic versus vasogenic. In: Intracranial Pressure V. Berlin: Springer, (in press).Google Scholar
- 14.Tyson GW, Teasdale GM, Graham DI, McCulloch J: Cerebrovascular permeability following middle cerebral artery occlusion in the rat: The effect of halothane-induced hypotension. J Neurosurg (in press).Google Scholar