Treatment of Focal Cerebral Ischemia with Prostacyclin and Indomethacin

  • Issam Awad
  • John R. Little
  • Fred Lucas
  • Victor Skrinska
  • Robert Slugg
  • Ronald P. Lesser


An effective medical regimen for the treatment of focal cerebral ischemia has yet to be defined. Therapy ideally should be directed towards improving tissue perfusion, reducing edema, and increasing the tolerance of cerebral tissue, particularly neurons, to the effects of ischemia1. It is unlikely that a single agent will be found to accomplish all these goals. Recent investigations have suggested that progressive microcirculatory impairment5,17,21 and intravascular coagulopathy12 occur in the ischemic brain. Other studies have described increased resistance of pial collateral arteries following experimental middle cerebral artery (MCA) occlusion23. Although it is not known to what extent this microcirculatory impairment contributes to the progression of ischemic changes and neurological damage, it is felt that maintenance of the cerebral microcirculation may enhance the delivery of oxygen and substrate, and potentially allow delivery of other therapeutic agents to the core area of ischemia.


Middle Cerebral Artery Occlusion High Pressure Liquid Chromatography Focal Cerebral Ischemia Untreated Animal Evans Blue 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Issam Awad
    • 1
  • John R. Little
    • 1
  • Fred Lucas
    • 1
  • Victor Skrinska
    • 1
  • Robert Slugg
    • 1
  • Ronald P. Lesser
    • 1
  1. 1.Section of Cerebrovascular Surgery, Department of NeurosurgeryCleveland Clinic FoundationClevelandUSA

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