Treatment of Focal Cerebral Ischemia with Prostacyclin and Indomethacin
An effective medical regimen for the treatment of focal cerebral ischemia has yet to be defined. Therapy ideally should be directed towards improving tissue perfusion, reducing edema, and increasing the tolerance of cerebral tissue, particularly neurons, to the effects of ischemia1. It is unlikely that a single agent will be found to accomplish all these goals. Recent investigations have suggested that progressive microcirculatory impairment5,17,21 and intravascular coagulopathy12 occur in the ischemic brain. Other studies have described increased resistance of pial collateral arteries following experimental middle cerebral artery (MCA) occlusion23. Although it is not known to what extent this microcirculatory impairment contributes to the progression of ischemic changes and neurological damage, it is felt that maintenance of the cerebral microcirculation may enhance the delivery of oxygen and substrate, and potentially allow delivery of other therapeutic agents to the core area of ischemia.
KeywordsMiddle Cerebral Artery Occlusion High Pressure Liquid Chromatography Focal Cerebral Ischemia Untreated Animal Evans Blue
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- 2.Ames A, Wright RL, Kowada MD: Cerebral ischemia II: No-reflow phenomenon. Am J Pathol 52: 437–453 (1968).Google Scholar
- 4.Cammermeyer J: An evaluation of the significance of the “dark” neuron. Ergebn Anat Entwickl 36: 1–61 (1962).Google Scholar
- 5.Crowell RM, Olsson Y: Observations on the microvasculature in focal cerebral ischemia and infarction. In: Cerebral Vascular Diseases 8, McDowell FH, Brannan RW (Eds), Grune and Stratton, New York: 77–88 (1973).Google Scholar
- 7.Dodson RF, Kawamura Y, Aoyagi M: A comparative evaluation of the ultrastructural changes following induced cerebral infarction in the squirrel monkey and baboon. Cytobios 8: 175–182 (1973).Google Scholar
- 23.Matsuoka Y, Hossman KA: The effect of induced hypertension on pial artery micropressure after middle cerebral artery occlusion in cats. J Cerebral Blood Flow and Metabolism 1: S163–S165 (1981).Google Scholar
- 27.Skrinska V, Lucas FV: Isolation of prostacyclin from whole blood. Prostaglandins 22: 365–375 (1981).Google Scholar
- 29.Waltz AG, Wanek AR, Anderson RE: Comparison of analytic methods for calculation of cerebral blood flow after intracarotid injection of 133Xe. J Nucl Med 13: 66–72 (1980).Google Scholar