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Cerebral Blood Flow, AJDO2 & CMRO2 in Comatose Children

  • David Swedlow
  • Tim Frewen
  • M. Watcha
  • Derek A. Bruce

Abstract

The relationship between coma, cerebral edema, cerebral blood flow and cerebral metabolism has been defined in adult patients over the last decade. In metabolic coma, the metabolism may be depressed or normal and CBF is generally a reflection of brain metabolism with metabolic regulation being preserved. Following head trauma, the majority of adults exhibit decreased CMR02 and proportional decrease in CBF, also suggesting intact metabolic regulation. Recently, reports of increased CBF in the face of a decreased CMR02 have been reported post trauma2,3. This relative hyperemia has been reported to carry a poor prognosis. There is little information on the state of cerebral blood flow and metabolism in comatose children and the following study reports on determinations of global flow and oxygen metabolism in 18 comatose children.

Keywords

Cerebral Blood Flow Brain Edema Systemic Arterial Pressure Follow Head Trauma Jugular Venous Bulb 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bruce DA, Alavi A, Bilaniuk L, Dolinskas C, Obrist W, Uzzell B: Diffuse cerebral swelling following head injuries in children: The syndrome of “malignant brain edema”. J Neurosurg 54: 170–178 (1981).CrossRefGoogle Scholar
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    Enevoldsen EM, Cold G, Jensen FT, Malmros R: Dynamic changes in regional CBF, intraventricular pressure, CSF pH and lactate levels during the acute phase of head injury. J Neurosurg 44: 191–214 (1976).CrossRefGoogle Scholar
  3. 3.
    Obrist WD, Gennarelli TA, Segua H, Dolinskas CA, Langfitt TW: Relation of cerebral blood flow and neurological status and outcome in head injured patients. J Neurosurg 51: 292–300 (1979).CrossRefGoogle Scholar
  4. 4.
    Swedlow D, Lewis: Measurement of cerebral blood flow in children. Anaesthesiology 53: 5160 (1980).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • David Swedlow
    • 1
  • Tim Frewen
    • 2
  • M. Watcha
    • 2
  • Derek A. Bruce
    • 3
  1. 1.Children’s HospitalUniversity of Pennsylvania School of MedicineUSA
  2. 2.Children’s Hospital of PhiladelphiaPhila.USA
  3. 3.University of Pennsylvania School of MedicineUSA

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