Dissociation Between Blood Flow and Metabolic Disturbances in Edema Associated with Experimental Abscess in Cats
The relationship between formation of vasogenic edema, blood flow and metabolism has been studied by several authors both under clinical and experimental conditions. The results obtained were equivocal: blood flow either increased or decreased, and metabolic activity could be disturbed4,5,7,13. Some controversy may be due to the fact, that in most of the previous studies the dilution effect of edema on flow and metabolites was not considered. The volume increase of edematous tissue, particularly that of the white matter, may be considerable, and changes may be falsely interpreted as hemodynamic or metabolic disturbance, when the values obtained are referred to fresh rather than to dry weight of tissue. Another source of confusion may be an increase in intracranial pressure. If the resulting reduction of cerebral perfusion pressure exceeds the limits of autoregulatory capacity, ischemiC alterations may be superimposed on those induced by brain edema. A correct interpretation of metabolic and hemodynamic changes associated with edema, therefore, is possible only when both intracranial and systemic arterial pressures are known.
KeywordsWhite Matter Brain Edema Cerebral Perfusion Pressure Brain Abscess Metabolic Disturbance
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