Dissociation Between Blood Flow and Metabolic Disturbances in Edema Associated with Experimental Abscess in Cats

  • Hans-Werner Bothe
  • Walter van den Kerckhoff
  • Wulf Paschen
  • Thomas Wallenfang
  • Konstantin-Alexander Hossman


The relationship between formation of vasogenic edema, blood flow and metabolism has been studied by several authors both under clinical and experimental conditions. The results obtained were equivocal: blood flow either increased or decreased, and metabolic activity could be disturbed4,5,7,13. Some controversy may be due to the fact, that in most of the previous studies the dilution effect of edema on flow and metabolites was not considered. The volume increase of edematous tissue, particularly that of the white matter, may be considerable, and changes may be falsely interpreted as hemodynamic or metabolic disturbance, when the values obtained are referred to fresh rather than to dry weight of tissue. Another source of confusion may be an increase in intracranial pressure. If the resulting reduction of cerebral perfusion pressure exceeds the limits of autoregulatory capacity, ischemiC alterations may be superimposed on those induced by brain edema. A correct interpretation of metabolic and hemodynamic changes associated with edema, therefore, is possible only when both intracranial and systemic arterial pressures are known.


White Matter Brain Edema Cerebral Perfusion Pressure Brain Abscess Metabolic Disturbance 
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  1. 1.
    Atkinson DE: The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 5, 4030–4034 (1968).CrossRefGoogle Scholar
  2. 2.
    Bohl I, Wallenfang T, Bothe HW, Schürmann K: The effect of glucocorticoids in the combined treatment of experimental brain abscess in cats. Adv Neurosurg 9: 125–133 (1981).CrossRefGoogle Scholar
  3. 3.
    Bothe HW, Wallenfang T, Khalifa A, Schürmann K: The relationship between brain edema, energy metabolism, glucose content and rCBF investigated by artificial brain abscess in cats. Adv Neurosurg 10, in press.Google Scholar
  4. 4.
    Bruce DA, Vapalahti M, Schutz H, Langfitt TW: rCBF, CMRO2 and intracranial pressure following a local cold injury of the cortex. In: Intracranial Pressure, Experimental and Clinical Aspects, Brock M, Dietz H (Eds) Springer Berlin, Heidelberg, New York: 85–89 (1972).CrossRefGoogle Scholar
  5. 5.
    Frei HJ, Wallenfang T, Pöll W, Reulen HJ, Schubert R, Brock M: Regional cerebral blood flow and regional metabolism in cold induced edema. Acta Neurochir 29: 15–28 (1973).CrossRefGoogle Scholar
  6. 6.
    Hamer J, Hoyer S, Alberti E, Stoeckel H: Cerebral blood flow and metabolism at different levels of decreased cerebral perfusion pressure induced by raised intracranial pressure and normovolemic arterial hypotension. In: Cerebral Circulation and Metabolism, Langfitt TW, McHenry LC, Reivich M, Wollman H (Eds) Springer Berlin, Heidelberg, New York: 184–187 (1975).CrossRefGoogle Scholar
  7. 7.
    Hossmann KA, Blöink M, Wilmes F, Wechsler W: Experimental peritumoral edema of the cat brain. Adv Neurol 28: 323–340 (1980).Google Scholar
  8. 8.
    Klatzo I: Pathophysiological aspects of brain edema. In: Steroids and Brain Edema, Reulen HJ, Schürmann K, (Eds) Springer Berlin-Heidelberg-New York: 1–8 (1972).CrossRefGoogle Scholar
  9. 9.
    Kogure K, Furones AO: A pictorial representation of endogenous brain ATP by a bioluminescent method. Brain Res 154: 273–284 (1978).CrossRefGoogle Scholar
  10. 10.
    Lienert GA: Verteilungsfreie Methoden in der Biostatistik, Bd I, 212–341, Meisenheim: Anton Hain KG (1973).Google Scholar
  11. 11.
    Lowry OH, Passonneau JV, Hasselberger FX, Schulz DW: Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J Biol Chem 239: 18–29 (1964).Google Scholar
  12. 12.
    Marmarou A, Schulman K, Shapiro K, Poll W: The time course of brain tissue pressure and local CBF in vasogenic edema. In: Dynamics of Brain Edema. Pappius HM, Feindel W (Eds) Springer Berlin, Heidelberg, New York: 113–121 (1976).CrossRefGoogle Scholar
  13. 13.
    Marmarou A, Takagi H, Shulman K: Biomechanics of brain edema and effects on local cerebral blood flow. In Brain Edema, Cervos Navarro J, Ferszt R (Eds) Adv Neurol 28: 345–358 (1980).Google Scholar
  14. 14.
    Paschen W, Niebuhr I, Hossmann KA: A bioluminescence method for the demonstration of regional glucose distribution in brain slices. J Neurochem 36: 513–517 (1981).CrossRefGoogle Scholar
  15. 15.
    Reulen HJ, Mezihradsky F, Enzenbach R, Marguth F: Electrolytes, fluids and energy metabolism in human cerebral edema. Arch Neurol 21: 517–525 (1969).CrossRefGoogle Scholar
  16. 16.
    Rudolph AM, Heymann MA: The circulation of the fetus in utero. Circ Res 21: 163–185 (1967).CrossRefGoogle Scholar
  17. 17.
    Siesjö BK: the bicarbonate/carbonic acid buffer system of the cerebral cortex of cats, as studied in tissue homogenates. Acta Neurol Scand 38: 98–120 (1962).CrossRefGoogle Scholar
  18. 18.
    Siesjö BK: Brain energy metabolism, John Wiley & Sons, New York, Brisbane, Toronto: (1978).Google Scholar
  19. 19.
    Sokoloff L: Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J CBF Metabol 1: 7–26 (1981).Google Scholar
  20. 20.
    Wallenfang T, Bothe HW: Experimental brain abscess in cats: The effect on edema and regional metabolism of antibiotics alone and in combination with dexamethasone and their influence on the antibody titre in serum. Neurochirurgia Suppl, 72 (1981).Google Scholar
  21. 21.
    Welsh FA, Rieder W: Evaluation of in situ freezing of cat brain by NADH fluorescence. J Neurochem 31: 299–309 (1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Hans-Werner Bothe
    • 1
  • Walter van den Kerckhoff
    • 1
  • Wulf Paschen
    • 1
  • Thomas Wallenfang
    • 2
  • Konstantin-Alexander Hossman
    • 1
  1. 1.Max-Planck-Institut für Neurologische ForschungAbteilung für experimentelle NeurologieCologneGermany
  2. 2.Neurochirurgische UniversitätsklinikMainzGermany

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