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Peritumoral Brain Edema: Effects of Methylprednisolone on Local Cerebral Blood Flow, Glucose Utilization and Capillary Permeability

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Recent Progress in the Study and Therapy of Brain Edema
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Abstract

Management of brain edema associated with tumor is extremely important for the treatment of brain tumor patients. Mass effects of the peritumoral edema often exceed those of the tumor itself. However, the mechanism of edema formation and the pathophysiology of this type of edema remain uncertain. Our previous study11 revealed that water and electrolyte content in the peritumoral brain tissue were similar to that of plasma, thus indicating that peritumoral brain edema is of the vasogenic type.

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References

  1. Blasberg RG, Lajtha A: A substrate specificity of steady state amino acid uptake in mouse brain slices. Arch Biochem Biophys 112: 361–377 (1965).

    Article  Google Scholar 

  2. Blasberg RG, Groothuis D, Molnar P: Application of quantitative autoradiographic measurements in experimental brain tumor models, Sem in Neurol 1: 203–221 (1981).

    Article  Google Scholar 

  3. Ehrenkranz JRL, Posner JB: Adrenocorticosteroid hormones. In: Brain Metastasis Weiss L, Gilbert HA, Posner JB (Eds) GK Hall & Co. Boston 115–133 (1980).

    Google Scholar 

  4. Kety SS: Measurement of local flow by the exchange of an inert diffusible substance. Methods Med Res 8: 228–236 (1960).

    Google Scholar 

  5. Ohno K, Pettigrew K, Rapoport S: Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat. Am J Physiol 235: H299–H307 (1978).

    Google Scholar 

  6. Pappius HM, Savaki HE, Fieschi C, Rapoport SI, Sokoloff L: Osmotic opening of the blood-brain barrier and local cerebral glucose utilization. Ann Neurol 5: 211–219 (1979).

    Article  Google Scholar 

  7. Pappius HM: Local cerebral glucose utilization in thermally traumatized rat brain. Ann Neurol 9: 484–491 (1981).

    Article  Google Scholar 

  8. Reulen HJ, Hadjidimos A, Schürmann K: The effect of dexamethasone on water and electrolyte content and on rCBF in perifocal brain edema in man. In Steroids and Brain Edema Reulen HJ, Schürmann K, Springer Berlin, 239–252 (1972).

    Google Scholar 

  9. Sakurada O, Kennedy C, Jehle J, Brown JD, Carbin GL: Measurement of local cerebral blood flow with iodo(14C)antipyrine. Am J Physiol 3: H59–H66 (1978).

    Google Scholar 

  10. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M: The 14C-deoxyglucose method for the measurement of local cerebral glucose utilization. Theory, procedure and normal values in the conscious and aneshtetized albino rat. J Neurochem 28: 897–916 (1977).

    Article  Google Scholar 

  11. Yamada K, Bremer AM, West CR: Effects of dexamethasone on tumor-induced brain edema and its distribution in the brain of monkeys. J Neurosurg 50: 361–367 (1979).

    Article  Google Scholar 

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© 1984 Plenum Press, New York

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Yamada, K., Hayakawa, T., Ushio, Y., Kato, A., Yamada, N., Mogami, H. (1984). Peritumoral Brain Edema: Effects of Methylprednisolone on Local Cerebral Blood Flow, Glucose Utilization and Capillary Permeability. In: Go, K.G., Baethmann, A. (eds) Recent Progress in the Study and Therapy of Brain Edema. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4616-6_33

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  • DOI: https://doi.org/10.1007/978-1-4684-4616-6_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4618-0

  • Online ISBN: 978-1-4684-4616-6

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