The Water Content of White Matter After Head Injury in Man
Edema, increased cerebral blood volume and outflow obstruction have been suggested as possible causes of raised intracranial pressure (ICP) after head injury. Studies following experimental head injury in animals have produced conflicting results; Tornheim and McLaurin15 found an increase in cerebral water content in the contused hemisphere whereas using a fluid percussion model Corales et al2 were unable to show any increase. While brain water has been measured directly in man3,7,11,12,13,14 it has not been measured after head injury and conclusions about brain water after head injury have been based on indirect measurements utilizing the CT scan1,8. To overcome this and in order to determine the relationship between brain water and intracranial pressure we have measured directly the water content of the white matter of brain tissue taken from severely head injured patients during operation.
KeywordsHead Injury Brain Edema Cerebral Blood Volume Brain Water Content Diffuse Lesion
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