CT Enhancement After Three Hours of Continuous Contrast — Infusion in Acute Stage of Cerebral Infarction
There is general agreement that in stroke victims, enhancement of the infarcted tissue on the computed tomography (CT) image occurs 2–4 weeks after the stroke episode1,8,11,13,15,16. On the other hand, a hypodense mass effect due to brain edema develops within a week of the episode7,10,11, 13,16. Therefore, the question arises whether in human cerebral infarction the blood-brain barrier (BBB) change is an earlier event than is usually accepted3. To obtain a high blood concentration of the contrast medium for a prolonged period of time, we employed long-term continuous infusion of contrast medium rather than the conventional bolus injection, to study CT enhancement during the acute phase of cerebral infarction.
KeywordsCompute Tomography Image Contrast Enhancement Mass Effect Brain Edema Drip Infusion
Unable to display preview. Download preview PDF.
- 2.Gado MH, Phelps ME, Coleman RE: An extravascular component of contrast enhancement in cranial computed tomography. Part 1. The tissue-blood ratio of contrast enhancement. Radiol 117: 589–593 (1975).Google Scholar
- 3.Harrison MGJ: Ischémie edema in stroke (Letters to Editor) Stroke 12: 888 (1981).Google Scholar
- 4.Huckman MS: Clinical experience with the intravenous infusion of iodinated contrast material as an adjunct to computed tomography. Surg Neurol 4: 297–317 (1975).Google Scholar
- 5.Ito U, Kito K, Okada K, Ohno K, Tomita H, Inaba Y: Brain edema and EEG during ischemia and after restoration of blood flow. This Symposium.Google Scholar
- 6.Ito U, Ohno K, Yamaguchi T, Takei H, Tomita H, Inaba Y: Effect of hypertension on blood-brain barrier change after restoration of blood flow in post-ischemic gerbil brain. An electron-microscopic study. Stroke 11: 606–611 (1980).Google Scholar
- 8.Norton GA, Kishore PRS, Lin J: CT contrast enhancement in cerebral infarction. J Roentgenol 131: 881–885 (1978).Google Scholar
- 9.Paulson OB, Lassen NA, Skinoj E: Regional cerebral blood flow in apoplexy without arterial occlusion. Neurol 20: 125–138 (1970).Google Scholar
- 13.Valk J: Computed tomography and cerebral infarctions. Raven Press, New York pp 55–143 (1980).Google Scholar
- 14.Westergaard E, Go KG, Klatzo I, Spatz M: Increased permeability of cerebral vessels to horseradish peroxidase induced by ischemia in mongolian gerbils. Acta Neuropathol 35: 307–325 (1976).Google Scholar
- 15.Wings SD, Norman D, Pollack JA, Newton TH: Contrast enhancement of cerebral infarcts in computed tomography. Radiol 121: 89–92 (1976).Google Scholar
- 16.Yock DH, Marshall WH: Recent ischémie brain infarcts at computed tomography: Appearances pre-and postcontrast infusion. Radiol 117: 599–603 (1975).Google Scholar