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Thermal Analysis on the State of Free and Bound Water in Normal and Edematous Brains

  • Masahiro Furuse
  • Takami Gonda
  • Hiroji Kuchiwaki
  • Nagatoshi Hirai
  • Suguru Inao
  • Naoki Kageyama

Abstract

Analysis of the state of tissue water in brain parenchyma is essential for studying the pathogenesis of brain edema. However, due to technological problems the state of water in tissue remains difficult to assess. Ambo1 attempted in 1951 to measure bound water by the cobalt chloride method applied to formalin-fixed brain. Utilizing NMR, Go and Edzes5 studied in 1975 the state of protons of fresh brain tissue and found an increase in relaxation time of edematous brain tissue compared to controls. An increase of relaxation time is considered to result from an increase of free water. However, absolute values of free and bound water have not been determined yet.

Keywords

Differential Scanning Calorimetry Free Water Brain Edema Tissue Water Brain Water Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ambo H: Experimental swelling of the brain and its bound water, Acta Pathol Japon 1, 63–71 (1951).Google Scholar
  2. 2.
    Ambo H: Klinische Bemerkungen ueber die Hirnschwellung, Auf Ergebnissen der experimentellen Untersuchungen basierend. Folia Psychiat Neurol Japon 15, 40–71 (1961).Google Scholar
  3. 3.
    Bering EA: Water exchange of central nervous system and cere-brospinal fluid. J Neurosurg 9, 275–287 (1952).CrossRefGoogle Scholar
  4. 4.
    Furuse M, Kuchiwaki H, Gonda T, Kageyama N, Kawajiri H, Kontani J: Thermoanalytical investigation on the state of free and bound water in normal and edematous brains, J CBF & Metab 1 (supl. l) 154–155 (1981).Google Scholar
  5. 5.
    Go KG, Edzes HT: Water in brain edema, Observation by pulsed nuclear magnetic resonance technique, Arch Neurol 32: 462–465 (1975).CrossRefGoogle Scholar
  6. 6.
    Kuntz ID, Kauzmann W: Hydration of proteins and poly-peptides. Adv Protein Chem 38: 239–345 (1974).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Masahiro Furuse
    • 1
  • Takami Gonda
    • 1
  • Hiroji Kuchiwaki
    • 1
  • Nagatoshi Hirai
    • 1
  • Suguru Inao
    • 1
  • Naoki Kageyama
    • 1
  1. 1.Department of NeurosurgeryNagoya University School of MedicineShowa-KuJapan

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