Thermal Analysis on the State of Free and Bound Water in Normal and Edematous Brains
Analysis of the state of tissue water in brain parenchyma is essential for studying the pathogenesis of brain edema. However, due to technological problems the state of water in tissue remains difficult to assess. Ambo1 attempted in 1951 to measure bound water by the cobalt chloride method applied to formalin-fixed brain. Utilizing NMR, Go and Edzes5 studied in 1975 the state of protons of fresh brain tissue and found an increase in relaxation time of edematous brain tissue compared to controls. An increase of relaxation time is considered to result from an increase of free water. However, absolute values of free and bound water have not been determined yet.
KeywordsDifferential Scanning Calorimetry Free Water Brain Edema Tissue Water Brain Water Content
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