Advertisement

Vasoactive Effects of Bradykinin on Cerebral Vessels and its Possible Role as a Mediator of Vasogenic Brain Edema

  • M. Wahl
  • A. Unterberg
  • A. Baethmann

Abstract

Formation of vasogenic brain edema is facilitated by arteri-olar dilation and venular constriction as well as an increase of vascular permeability. A previous study has shown that the cerebral water content is increased after ventriculo-cisternal perfusion with bradykinin5. In addition, uptake of plasma kininogen has been demonstrated in damaged brain1. Therefore, bradykinin may be involved in the formation and spreading of brain edema. Since only few and contradictory reports on the vasomotor effect of bradykinin on isolated cerebral arteries are available3,2 the aim of the present study was to test the vasomotor effect of bradykinin on cerebral vessels in vivo.

Keywords

Brain Edema Cerebral Vessel Pial Arteriole Vasogenic Brain Edema Vasomotor Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Baethmann A, Maier-Hauff K, Lange M, Kempski O: Activation of the kallikrein-kinin system in brain tissue secondary to cerebral injury and ischemia. J. Cereb. Blood Flow Metabol. 1, Suppl. 1, 218–219 (1981).Google Scholar
  2. 2.
    Hanko J, Hardebo JE, Owman Ch: Effects of various neuropeptides on cerebral blood vessels. J. Cereb. Blood Flow Metabol. 1, Suppl. 1, 346–347 (1981).Google Scholar
  3. 3.
    Toda N: Actions of bradykinin on isolated cerebral and peripheral arteries. Am. J. Physiol. 232, H267–H274 (1977).Google Scholar
  4. 4.
    Unterberg A, Maier-Hauff K, Wahl M, Schürer L, Lange M, Baethmann A: Cerebral uptake and consumption of plasma-kininogen in vasogenic brain edema; recent findings of kinin mechanisms. This meeting.Google Scholar
  5. 5.
    Unterberg A, Baethmann A, Geiger R: The kallikrein-kinin-system as mediator in cerebral edema. Agents and Actions, Suppl. 9: 402–407 (1981).Google Scholar
  6. 6.
    Wahl M, Kuschinsky W, Bosse O, Thurau K: Dependency of pial arterial and arteriolar diameter on perivascular osmolarity in the cat. A microapplication study. Circ. Res. 32, 162–169 (1973).CrossRefGoogle Scholar
  7. 7.
    Wahl M, Kuschinsky W: The dilatatory action of adenosine on pial arteries of cats and its inhibition by theophylline. Pflügers Arch. 362, 55–59 (1976).CrossRefGoogle Scholar
  8. 8.
    Wahl M, Kuschinsky W: The dilating effect of histamine on pialarteries of cats and its mediation by H2 receptors. Circ. Res. 44, 161–165 (1979).CrossRefGoogle Scholar
  9. 9.
    Wilkens HJ, Back N: Reversal of bradykinin action: Possible involvement of prostaglandins or dual receptors. Pharmacol. Res. Comm. 12, 411–422 (1980).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. Wahl
    • 1
  • A. Unterberg
    • 2
  • A. Baethmann
    • 2
  1. 1.Dept. PhysiologyUniv. of MunichGermany
  2. 2.Inst. Surg Res.Univ. of MunichGermany

Personalised recommendations