Brain Tissue Prostaglandins and Ischemic Edema: Cause or Coincidence?
Previous studies have suggested that “ischemic brain edema” has both cytotoxic and vasogenic features13. The mechanism for the formation of this edema is complicated, but it is established that extracellular ionic migration2 and protein extravasation5 play a role particularly if cerebral blood flow (CBF) is less than 7 ml/ 100 g/min. At this point it is known that disruption of cellular membranes occurs with maximal edema formation7. Following such damage to cell membranes, Wolfe and Coceani22 have emphasized that release of prostaglandins (PG) occurs. Edema formation at low levels of CBF is reduced by pretreatment with indomethacin and more effectively by dexamethasone12. The question arises, therefore, as to whether or not edema formation during severe ischemia is PG-mediated.
KeywordsCerebral Blood Flow Brain Edema Vasogenic Edema Brain Water Content Carotid Occlusion
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