Cerebral Blood Volume Changes During the Development of Brain Edema

  • George Mchedlishvili
  • Miroslaw Mossakowski
  • Micheal Itkis
  • Natalie Sikharulidze
  • Slowomir Januszewski


The excessive transfer of water from blood to brain tissue during the development of edema is dependent upon a series of interrelated circulatory, vascular and tissue factors. The circulatory factors have long since been the subject of research19,9,10. The most important role is certainly played by the intravascular pressure which is forcing the water across the vascular walls into the cerebral tissue9,10,8,12,4,l. The cerebral blood pressure (i.e. predominantly the pressure in the brain capillaries) is, on the one hand, dependent upon the systemic arterial and venous pressures, and, on the other hand, on the cerebral arterial resistance.


Brain Edema Cerebral Blood Volume Intravascular Pressure Brain Volume Change Systemic Venous Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Auer L: The role of cerebral perfusion pressure as origin of brain edema in acute arterial hypertension. Eur Neurol 15: 153–156 (1977).CrossRefGoogle Scholar
  2. 2.
    Bering EA: Water exchange of central nervous system and cere-brospinal fluid. J Neurosurg 9: 275–287 (1952).CrossRefGoogle Scholar
  3. 3.
    Blinkow SM, Gleser II: Das Zentralnervensystem in Zahlen und Tabellen. Jena: Gustav Fischer Verlag (1968).Google Scholar
  4. 4.
    Gannushkina IV, Shafranova VP: The differences of arterial autoregulation in gray and white matter in acute hypertension. In: Blood flow and metabolism in the brain, Harper M, Jennett B, Miller J et al (Eds), Edinburgh-London-New York: Churchill Livingstone, 5.31–5.35 (1977).Google Scholar
  5. 5.
    Greenberg JH, Alavi A, Reivich A, Kuhl D, Uzzell B: Local cerebral blood volume response to carbon dioxide in man Circ Res, 43: 324–331 (1978).Google Scholar
  6. 6.
    Haddy FJ, Scott JB, Grega GJ: Peripherial circulation: fluid transfer across the microvascular membrane. In: International Review of Physiology, volume 9, Cardiovascular Physiology II, Guyton AC, Cowley AW (Eds), Baltimore-London-Tokyo: University Park Press, 63–109 (1976).Google Scholar
  7. 7.
    Ito U, Ohno K, Nakamura R, Suganuma F, Inaba Y: Brain edema during ischemia after restoration of blood flow. Stroke 10: 542–547 (1979).CrossRefGoogle Scholar
  8. 8.
    Klatzo I, Wiśniewski H, Steinwall O, Streicher E: Dynamics of cold injury edema. In: Brain edema, Klatzo I, Seitelberger F (Eds) Springer New York, 554–563 (1967).CrossRefGoogle Scholar
  9. 9.
    Mchedlishvili GI, Akhobadze VA: The cerebral arterial system in brain injury and during traumatic edema. Physiol Bohemoslove-nica 10: 8–14 (1961).Google Scholar
  10. 10.
    Mchedlishvili GI, Akhobadze VA: The functional state of the capillary and venous systems of the brain in cerebral traumatic edema. Physiol Bohemoslovenica 10: 15–20 (1961).Google Scholar
  11. 11.
    Mchedlishvili GI: A chest-head preparation for investigation of the cerebral circulation. Bull exper Biol Med (Moscow) 53: 123–125 (1962).Google Scholar
  12. 12.
    Mchedlishvili GI, Kapuściński A, Nikolaishvili L: Mechanisms of postischemic brain edema: contribution of circulatory factors. Stroke 7: 410–416 (1976).CrossRefGoogle Scholar
  13. 13.
    Mchedlishvili G, Nikolaishvili L, Itkis M: Pathophysiological mechanisms of brain edema development: role of tissue factors. Stroke 10: 52–57 (1979).CrossRefGoogle Scholar
  14. 14.
    Mchedlishvili GI, Mossakowski M, Itkis ML: Changes in mechanical properties of brain tissue as factor of brain edema development. Neuropat Pol 18: 543–554 (1980).Google Scholar
  15. 15.
    Mchedlishvili GI, Sikharulidze NV, Itkis ML, Januszewski S: Cerebral venous pressure, its relation to systemic venous pressure and brain edema development. Bull exper Biol and Med (Moscow) 89: 14–16 (1980).Google Scholar
  16. 16.
    Mchedlishvili GI, Itkis ML, Sikharulidze NV: Mechanical properties of the brain during development of postischemic edema. Voprosy Neirokhirurgii (Moscow), no. 6 (in press) (1981).Google Scholar
  17. 17.
    Mchedlishvili GI: The brain pre-edema. J Neurosurg 54: 848 (1981).Google Scholar
  18. 18.
    Mchedlishvili GI, Lazriev L, Tsitsishvili A, Sikharulidze N: Ischemic changes in brain interstitial space volume. IRCS Med Sci 9: 399–400 (1981).Google Scholar
  19. 19.
    Meyer JS, Denny-Brown D: Studies of cerebral circulation in brain injury. 1. Validity of combined local cerebral electro-polarography, thermometry and steady potentials as an indicator of local circulatory and functional changes. EEG Clin Neuro-physiol 7: 511–528 (1955).CrossRefGoogle Scholar
  20. 20.
    Penn RD, Walser R, Ackerman L: Cerebral blood volume in man. Computer analysis of a computerized brain scan. J Amer Med Ass 234: 1154–1155 (1975).CrossRefGoogle Scholar
  21. 21.
    Phelps ME, Crubb RL, Ter-Pogossian MM: In vivo regional cerebral blood volume by X-ray fluorescence: validation of method. J appl Physiol 35: 741–747 (1973).Google Scholar
  22. 22.
    Raichle ME, Eichling JO, Straatmann MJ, Welch MJ, Larson KB, Ter-Pogossian MM: Blood-brain barrier permeability of 11C-labeled alcohols and 150-labeled water. Am J Physiol 230: 543–552 (1976).Google Scholar
  23. 23.
    Sklar FH, Bruke EF, Langfitt TW: Cerebral blood volume obtained with 51Cr-labeled red blood cells and RISA. J appl Physiol 24: 79–82 (1968).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • George Mchedlishvili
    • 1
  • Miroslaw Mossakowski
    • 2
  • Micheal Itkis
    • 1
  • Natalie Sikharulidze
    • 1
  • Slowomir Januszewski
    • 2
  1. 1.Laboratory of Physiology and Pathology of the Cerebral Circulation, I. Beritashvili Institute of PhysiologyGeorgian Academy of SciencesTbilisiUSSR
  2. 2.Department of Neuropathology, Medical Research CenterPolish Academy of SciencesWarsawPoland

Personalised recommendations