Brain Edema in Cerebral Malaria: A Comparative Clinical and Experimental, Ultrastructural and Histochemical Study

  • C. Jerusalem
  • T. Polder
  • K. Kubat
  • M. Wijers-Rouw
  • Phan Trinh


In several countries of the Western-Pacific region, for instance Vietnam and Cambodia, malaria tropica (P. falciparum) had become a serious problem because of the resistance of plasmodia to chloroquine (100%) quinine and Fansidar(R) (about 20%). Mortality among children hospitalized because of acute P. falciparum infection is about 48% while about 22% of adults die of this disease. The main cause of death is a cerebral syndrome with clinical manifestations of deep coma, convulsions and terminal cardiac and/or respiratory arrest.


Brain Edema Cerebral Malaria Perivascular Space Plasmodium Berghei Petechial Hemorrhage 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • C. Jerusalem
    • 1
  • T. Polder
    • 1
  • K. Kubat
    • 2
  • M. Wijers-Rouw
    • 1
  • Phan Trinh
    • 3
  1. 1.Dept. of Cytology and HistologyUniversity of NijmegenThe Netherlands
  2. 2.Dept. of Cytology and PathologyUniversity of NijmegenThe Netherlands
  3. 3.Choray HospitalHoChiMinh CityVietnam

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