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Basic Molecular Events Underlying Transendothelial Transport in Brain Capillaries

  • Ferenc Joó
  • András Mihály
  • Péter Temesvári
  • Ernó Dux

Abstract

Endothelial cells which are joined by tight junctions in the brain form a peculiar barrier restricting the movements of macro-molecules and many other solutes between blood and brain. So far. several enzymes including cholinesterases6,7, DOPA decarboxylase2 γ -glutamyl transpeptidase17. Na-K-activated adenosine triphospha-tase4,1, and other ATPases8,12 have been reported not only to be present in brain capillaries, but also to be involved in the regulation of blood-brain barrier permeability. Since the discovery of the importance of cyclic nucleotides in the mediation of the hormonal influences on different cellular functions, we have been trying to elucidate the possible role of cAMP and cGMP in the regulation of permeability of brain microvessels. Up to now, the following data have been collected:
  • dibutyryl (dibu) cAMP increases permeability and pinocytosis in brain capillaries9,

  • adenylate cyclase could be found in brain microvessels histochemically11,

  • histamine receptors — mainly of H2-type — are linked to the capillary adenylate cyclase as detected by biochemical measurements14,

  • the presence of guanylate cyclase was found in brain capillaries by means of histochemistry and biochemical measurements15.

Keywords

Adenylate Cyclase Brain Edema Guanylate Cyclase Adenylate Cyclase Activity Adenosine Triphosphatase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Ferenc Joó
    • 1
  • András Mihály
    • 2
  • Péter Temesvári
    • 3
  • Ernó Dux
    • 1
  1. 1.Laboratory of Molecular NeurobiologyInstitute of Biophysics, Biological Research CenterSzegedHungary
  2. 2.Department of AnatomyHistology and Embryology, University Medical SchoolSzegedHungary
  3. 3.Clinics of PediatricsUniversity Medical SchoolSzegedHungary

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