Aging at the Neuromuscular Junction
Aging is manifest in many ways. Some are subtle while others are quite pronounced. In the nervous system, aging is particularly evident, for there are distinct behavior changes. Impaired motor coordination and reduced physical strength are among the most apparent and widespread attributes of senescence. For example, the rates and the magnitudes of various reflex responses, including simple movements of a finger or a foot, generally decrease. This is associated with a progressive decline in muscle strength after about 25 years of age (Åstrand and Rodahl, 1977). Furthermore, the rate of decrease in strength is greater for the leg and trunk muscles than for the arm muscles.
KeywordsSynaptic Vesicle Nerve Terminal Neuromuscular Junction Phrenic Nerve Extensor Digitorum Longus
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