The Aging Cell Surface

Structural and Biochemical Alterations Associated with Progressive Subcultivation of Human Diploid Fibroblasts
  • Robert O. Kelley
  • Kathryn G. Vogel


The cell membrane is a complex fluid mosaic of lipid and protein (Bretscher, 1973; Singer and Nicolson, 1972; Steck, 1974; Shinitzky and Henkart, 1979) between the cellular interior and the immediate extracellular environment. It provides the foundation for the structural and molecular mechanisms that govern cell-to-cell interaction, external signal reception, cell adhesion and motility, and establishment and maintenance of cell shape. Signal reception and intercellular communication play important roles in the control of cell cycle kinetics and proliferation (Clarkson and Baserga, 1974). Proteins which effect cell shape and motility also participate in mitotic events and the interphase stages of G1, S, and G2 (Baserga, 1968), in addition to establishing and maintaining contact with other cells and/or their normal or artificial substrates (Adelstein et al., 1979; Weihing, 1979).


Cellular Aging Senescent Cell Late Passage Diploid Fibroblast Human Diploid Fibroblast 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Robert O. Kelley
    • 1
  • Kathryn G. Vogel
    • 2
  1. 1.Department of AnatomyThe University of New Mexico School of MedicineAlbuquerqueUSA
  2. 2.Department of BiologyThe University of New Mexico College of Arts and SciencesAlbuquerqueUSA

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