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Synthesis and Intracellular Transport of Mitochondrial Proteins

  • Matthew A. Harmey
  • Walter Neupert

Abstract

The biogenesis of the mitochondrion represents the result of a coordinated synergism between two distinct and spatially separate genetic systems. Not only are these two systems separate but they also have distinct modes of transcription and translation (Barrell et al., 1979; Borst, 1981; Borst and Grivell, 1978, 1981). Genetic and inhibitor studies on the development of mitochondria established that the majority of mitochondrial proteins are coded for by the nuclear DNA and are the products of translation on the cytoplasmic ribosomes (Lamb et al., 1968; Schatz and Mason, 1974; Neupert and Schatz, 1981; Heinrich, 1982). As the protein constituents of mitochondria are distinct from the bulk of cellular proteins, some mechanism must exist for the sorting of proteins destined for the mitochondria.

Keywords

Membrane Potential Outer Membrane Precursor Protein Mitochondrial Protein Neurospora Crassa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Matthew A. Harmey
    • 1
  • Walter Neupert
    • 2
  1. 1.Department of BotanyUniversity College DublinDublinIreland
  2. 2.Institute of BiochemistryUniversity of GöttingenGöttingenWest Germany

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