The Gastric H,K-ATPase
The secretion of hydrochloric acid by the stomach is a particularly remarkable example of biological active transport. A luminal pH of 0.8 is generated. Since the average cytosolic pH is 7.7, the proton gradient across the gastric mucosa is more than a million-fold. Ion gradients found across other mammalian tissues are smaller by several orders of magnitude, raising the question of whether the gastric pump works by the same mechanism as the more extensively studied ATP-driven Na,K- and Ca-pumps.
KeywordsATPase Activity Parietal Cell Nucleotide Site Oxyntic Cell Microsomal Vesicle
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