Intrinsic Protein—Lipid Interactions in Biomembranes
The nature of the interface between membrane lipids and intrinsic protein molecules has been the subject of a good deal of research in recent years. An understanding of these interactions are important in understanding the functioning of the membrane as a whole. A number of increasingly sophisticated physical techniques have been applied to the study of protein—lipid interactions, but due to the complex interplay which can occur in even model membranes, interpretation of the data is often difficult since different techniques can yield apparently contradictory results.
KeywordsArrhenius Plot Cytochrome Oxidase Lateral Diffusion Lipid Molecule Fluorescence Recovery After Photobleaching
Unable to display preview. Download preview PDF.
- Alonso, A., Restall, C. J., Turner, M., Gomez-Fernandez, J. C., Goni, F. M., and Chapman, D., Protein—lipid interactions and differential scanning calorimetric studies of bacteriorhodopsin reconstituted lipid—water systems, Biochim. Biophys. Acta 689:283–289.Google Scholar
- Cherry, R. J., 1978, Measurement of protein rotational diffusion in membranes by flash photolysis, in: Methods in Enzymology, Vol. LIV (S. Fleischer and L. Packer, eds.), Academic Press, New York.Google Scholar
- Kang, S-Y., Kinsey, R. A., Rajan, S., Gutowsky, H. S., Gadebridge, M. G., and Oldfield, E., 1981, Protein—lipid interactions in biological and model membrane systems. Deuterium NMR of A. laidlawii B., E. coli and cytochrome systems containing specifically deuterated lipids, J. Biol. Chem. 256:1155–1159.PubMedGoogle Scholar
- Kimbelberg, H. K., and Paphadjopoulous, D., 1974, Effects of phospholipid acyl chain fluidity and cholesterol on (Na+ + K+-stimulated adenosine triphosphate, J. Biol. Chem. 249:1071–1080.Google Scholar
- Leaver, J., Alonso, A., Durrani, A. A., and Chapman, D., 1984, The biosynthetic incorporation of diacetylenic fatty acids into the biomembranes of Acholeplasma laidlawii A cells and the polymerization of the biomembranes by UV irradiation, Biochim. Biophys. Acta, in press.Google Scholar
- Oldfield, E., Gilmore, R., Glasser, M., Gutowsky, H. S., Hshung, J. C., Kang, Y-S., King, T. E., Meadows, M., and Rice, D., 1978, Deuterium nuclear magnetic resonance investigation of the effects of proteins and Polypeptides on hydrocarbon chain order in model membrane systems, Proc. Natl. Acad. Sci. USA 75:4657–4660.PubMedCrossRefGoogle Scholar
- Overath, P., and Thilo, L., 1978, Structural and functional aspects of biological membranes revealed by lipid phase transitions, in: International Review of Biochemistry, Vol. 19 (J. C. Metcalfe, ed.), University Park Press, Baltimore, pp. 1–44.Google Scholar
- Poon, R., Richards, J. M., and Clark, W. R., 1981, The relationship between plasma membrane lipid composition and physical—chemical properties. II. Effect of phospholipid fatty acid modulation of plasma membrane physical properties and enzymic activities, Biochim Biophys. Acta 649:58–66.PubMedCrossRefGoogle Scholar
- Razi-Naqvi, K., Gonzalez-Rodriguez, J., Cherry, R. J., and Chapman, D., 1973, Spectroscopic technique for studying protein rotation in membranes, Nature New Biol. 245-251.Google Scholar