Calcium Ions, Enzymes, and Cell Fusion

  • Jack A. Lucy


Membrane fusion is a phenomenon of major importance in cell biology. It embraces events at the subcellular level, e.g., ndocytcosis and exocytosis, and it is an essential dynamic component of secretion, membrane flow, and lysosomal activity. Cell fusion is a special case of membrane fusion that occurs naturally in a comparatively small number of situations. Of these, fertilization and the fusion of myoblasts in the development of skeletal muscle are probably the most extensively investigated. There are also, however, a number of experimental ways of inducing cells to fuse artificially by, for example, treating them with viruses, e.g., Sendai virus, with chemicals, e.g., Poly(ethylene glycol), and most recently by the application of electrical forces (Zimmermann, 1982). In addition to its physiological significance, cell fusion has therefore recently become valuable as a laboratory tool, particularly in the production of hybridoma cells that secrete monoclonal antibodies.


Benzyl Alcohol Human Erythrocyte Cell Fusion Fusion Reaction Membrane Fusion 
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© Plenum Press, New York 1985

Authors and Affiliations

  • Jack A. Lucy
    • 1
  1. 1.Department of Biochemistry and Chemistry, Royal Free Hospital School of MedicineUniversity of LondonLondonEngland

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