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The Relationship between Metabolism and Mutagenicity of Two Cyclic Nitrosamines

  • James G. Farrelly
  • Lanny I. Hecker
Part of the Topics in Chemical Mutagenesis book series (TCM, volume 1)

Abstract

Animal studies with a large number of nitrosamines have demonstrated that different members of this chemical family can induce tumors in a remarkable range of mammalian tissues. It also appears that, to exert a biological effect, these carcinogens must first be activated by an appropriate enzyme system. Convincing evidence has accrued that indicates that the most important pathway for such activations is α-hydroxylation.(1–14) When the a-hydrogens of a nitrosamine are replaced with methyl groups, both carcinogenicity(3,4,6) and mutagenicity(13,15,17) are drastically reduced. Replacement of the α-hydrogens with deuterium also results in a reduction in carcinogenic potency.(5,18,19)

Keywords

Liver Microsome Succinic Semialdehyde Microsomal Metabolism Hepatocellular Tumor Microsomal Oxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this chapter

NPYR

nitrosopyrrolidine

NHEX

nitrosohexamethyleneimine

THF

tetrahydrofuran

HPLC

high-pressure liquid chromatography

HEPES

N-2-hydroxyethvlpiperazine-N'-2-ethanesulfonic

NMCE

nonmethylene chloride extractable

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • James G. Farrelly
    • 1
  • Lanny I. Hecker
    • 1
  1. 1.Chemical Carcinogenesis ProgramNCI-Frederick Cancer Research FacilityFrederickUSA

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