The Relationship between the Carcinogenicity and Mutagenicity of Nitrosamines in a Hepatocyte-Mediated Mutagenicity Assay

  • Carol A. Jones
  • Eliezer Huberman
Part of the Topics in Chemical Mutagenesis book series (TCM, volume 1)


Carcinogenesis is a complex process in which tumors develop from cells that have undergone a hereditary change from the normal phenotype to malignancy. A fraction of chemicals in the environment are capable of efficiently inducing such a change. While the exact mechanism of the malignant transformation is as yet not understood, it is widely believed that it is initiated as a result of interactions between the carcinogen and the cellular DNA, resulting in mutation(s) or mutationlike changes in the genes controlling cell growth and differentiation.(1–4)


Chemical Carcinogen Chemical Carcinogenesis Polycyclic Hydrocarbon Carcinogenic Potency Spontaneous Mutant Frequency 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Carol A. Jones
    • 1
  • Eliezer Huberman
    • 1
  1. 1.Division of Biological and Medical ResearchArgonne National LaboratoryArgonneUSA

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