Structural Basis for Mutagenic Activity of N-Nitrosamines in the Salmonella Histidine Reversion Assay
N-nitrosamines comprise a very important group of chemicals to which human beings are constantly exposed through beverages, food, medicines, cosmetics, tobacco products, and also at the work place in industry. The first report by Magee and Barnes(1) nearly 25 years ago that nitrosodimethylamine (NDMA) caused tumors in experimental animals initiated an unbounded interest among researchers throughout the world to assess the biological hazard caused by these compounds.
KeywordsMutagenic Activity Mixed Function Oxidase Agar Overlay Tumor Production Nipecotic Acid
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