N-Nitrosamine Mutagenicity Using the Salmonella/Mammalian-Microsome Mutagenicity Assay

  • A. W. Andrews
  • W. Lijinsky
Part of the Topics in Chemical Mutagenesis book series (TCM, volume 1)


The Salmonella / mammalian-microsome mutagenicity assay has been used extensively to test a variety of chemicals.(1) The results of many of the assays employed soon after the Ames test began to gain worldwide acceptance showed that nitrosamines, as a chemical class, did not demonstrate a consistent correlation between mutagenicity and carcinogenicity.(2) However, the more this testing was used, the more information was uncovered that showed the flexibility and adaptability of the assay.


Mutagenic Activity Liver Homogenate Potent Mutagen Mutagenic Response Of300 Chemical 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. W. Andrews
    • 1
  • W. Lijinsky
    • 2
  1. 1.Program Resources Inc., Chemical Carcinogenesis Program, LBI-Basic Research ProgramNCI-Frederick Cancer Research FacilityFrederickUSA
  2. 2.Chemical Carcinogenesis ProgramNCI-Frederick Cancer Research FacilityFrederickUSA

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