MAP2 (Microtubule-Associated Protein 2)

  • Richard B. Vallee


Microtubules are known to play a role in a wide variety of cellular processes. The major component of these structures is tubulin, a globular protein that makes up the microtubule wall. With the introduction of procedures for purifying microtubules (Weisenberg, 1972) it soon became clear that they contained a number of proteins in addition to tubulin (Borisy et al., 1975; Sloboda et al., 1975; Weingarten et al., 1975). These proteins have been referred to by the acronym MAPs, or microtubule-associated proteins (Sloboda et al., 1975). At least some of these proteins represent fine filamentous projections regularly arranged on the microtubule surface (Murphy and Borisy, 1975; Dentler et al., 1975). This suggests that the MAPs are involved in mediating the interaction of microtubules with other components of the cell, while tubulin itself makes up the structural backbone of the microtubule. In this view, understanding the MAPs may ultimately provide answers to two key questions regarding how cells work. What precisely do microtubules do in cells, and how do they do it?


Microtubule Assembly Microtubule Binding Tubulin Dimer Microtubule Protein Tubulin Subunit 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Richard B. Vallee
    • 1
  1. 1.Cell Biology GroupThe Worcester Foundation for Experimental BiologyShrewsburyUSA

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