Cell Shape and Membrane Receptor Dynamics
The cell surface is thought to be a major site for the transfer of information from the extracellular environment to the cell interior. Glycoprotein receptors, embedded in the plasma membrane, most likely mediate the process of information transfer since they provide a mechanism whereby cells can recognize particular signals in the environment which modulate cellular metabolism. Among the signals affecting cellular metabolism are soluble proteins, such as hormones and toxins, or macromolecular complexes, such as LDL and viruses, each of which bind to specific cell surface receptors to initiate their effects. Subsequent to ligand-receptor binding, many ligands and their receptors are internalized within coated vesicles which form endosomes that travel to specific cytoplasmic locations such as the Golgi-lysosome region where further processing occurs (Pastan and Willingham, 1981). The available evidence indicates that the movement of ligands, and perhaps their receptors, both at the cell surface and within the cytoplasm, is nonrandom and subject to control by the cytoskeleton (Albertini and Anderson, 1977; Edelman, 1976; Herman and Albertini, 1982; Oliver and Berlin, 1982; Rebhun, 1972).
KeywordsProgesterone Fibril Fluorescein Deuterium Azide
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