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Changes in Actin during Cell Differentiation

  • Kazuhiro Nagata
  • Yasuo Ichikawa

Abstract

Since the pioneering work by Loewy and Hoffman-Berling, the actomyosin system has been believed to have an important function not only in muscle cells but in nonmuscle cells (reviewed by Pollard and Weihing, 1974). Non-muscle cell actin was first purified from Physarum by Hatano and Oosawa (1966a,b). Success in identifying actin filaments as arrowhead figures in situ (Ishikawa et al., 1969), methods devised to purify nonmuscle cell actin (Gordon et al., 1976a), and the establishment of a DNase I inhibition assay that measures actin contents (Blikstad et al., 1978) show the great progress made in this field. In addition, there has been increased interest in various nonmuscle cell actins, functional and chemical differences among actin molecules from different sources, as well as differences in their control mechanisms.

Keywords

Conditioned Medium Actin Filament Actin Polymerization Crude Cell Extract Skeletal Muscle Myosin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Kazuhiro Nagata
    • 1
  • Yasuo Ichikawa
    • 1
  1. 1.Department of Cytochemistry, Chest Disease Research InstituteKyoto UniversityKyotoJapan

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