Monoclonal Antibodies to Intermediate Filament Proteins
Surgical pathologists base diagnoses upon characteristic features of neoplasms such as gland formation, papillary structures, and the spindle shape of tumor cells. Tumors without obvious differentiated features pose diagnostic problems because they lack the features that allow an accurate identification of tumor type. In such situations, one depends upon ultrastructural analysis by electron microscopy or relatively nonspecific histochemical stains to gain a clue as to the identity of the neoplasm. Clearly, what has been lacking in diagnostic pathology is a set of well-characterized tissue-specific reagents capable of distinguishing among different cells. Recently, anti-intermediate filament protein antibodies have been employed to distinguish cell type in poorly differentiated neoplasms.
KeywordsGlial Fibrillary Acidic Protein Stratum Corneum Intermediate Filament Squamous Epithelium Intermediate Filament Protein
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