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Abstract

Lysosomes (“lytic bodies”) are membrane-enclosed cytoplasmic organelles that have a low internal pH and contain numerous hydrolytic enzymes with acid pH optima in a latent state. Lysosomes are in fact the primary component of an extraordinarily dynamic and variegated membrane system, the lysosomal-vacuolar or lysosomal system, which serves as the intracellular digestive tract in virtually all eucaryotic cells. Lysosomes are unique among cell organelles in their morphological and enzymatic polymorphism and in the multiplicity of cell processes, both physiological and pathological, in which they participate. There have been many important advances in our knowledge of lysosomes since the appearance of the chapter on this subject in the first edition of the Handbook. In recent years, interest has focused on a number of new topics, including the chemical structure, biosynthesis, and intracellular transport of lysosomal enzymes; the role of the phosphomannosyl recognition marker and its receptor in lysosomal enzyme targeting; the regulation of lysosomal proteolysis and its role in intracellular protein degradation; receptor-mediated endocytosis of transport proteins, hormones , and other cell agonists; phagosome-lysosome fusion; lysosomotropic agents; and drug-induced lysosomal storage disorders.

Keywords

Lysosomal Enzyme Autophagic Vacuole Polyamine Synthesis Lysosomal Hydrolase Acidic Phospholipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Harold Koenig
    • 1
    • 2
  1. 1.Neurology ServiceVeterans Administration Lakeside Medical CenterChicagoUSA
  2. 2.Department of NeurologyNorthwestern University Medical SchoolChicagoUSA

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