The Smooth Endoplasmic Reticulum

  • Gérard Alonso


The concept of endoplasmic reticulum (ER) was introduced by electron mi-croscopists to designate a well-developed system of reticular membrane occurring in the internal regions of most cells. This specific intracellular membranous system is particularly important in neurons, where it forms a complex network of intraneuronal channels isolated from the surrounding neuroplasm. Three main components have generally been attributed to this intracellular membranous compartment: the rough endoplasmic reticulum (RER), the Golgi apparatus, and the smooth endoplasmic reticulum (SER). The particular aspect of the neuronal ER results from its highly regionalized organization: whereas the RER and Golgi complexes are rigorously confined to the perikarya and the proximal part of the dendrites, the SER is present in all neuronal sections, especially all along the dendritic and axonal processes, which may extend over distances thousands of times greater than the cell body diameter.


Golgi Apparatus Synaptic Vesicle Rough Endoplasmic Reticulum Axonal Transport Secretory Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Droz, B., and Koenig, H. L., 1970, Protein Metabolism in the Nervous System (A. Lajtha, ed.), Plenum Press, New York, pp. 93–108.CrossRefGoogle Scholar
  2. 2.
    Roberts, S., Zomzely, C. E., and Bondy, S. C., 1970, Protein Metabolism of the Nervous System (A. Lajtha, ed.), Plenum Press, New York, pp. 3–37.CrossRefGoogle Scholar
  3. 3.
    Droz, B., and Boyenval, J., 1975, J. Microsc. Biol Cell 23:45a-46a.Google Scholar
  4. 4.
    LeBlond, C. P., and Bennett, G., 1977, International Cell Biology (B. R. Brinkley and K. R. Porter, eds.), Rockefeller University Press, New York, pp. 326–336.Google Scholar
  5. 5.
    Farquhar, M. G., and Palade, G. E., 1981, J. Cell Biol 91:77s-103s.PubMedCrossRefGoogle Scholar
  6. 6.
    Palade, G., 1975, Science 189:347–358.PubMedCrossRefGoogle Scholar
  7. 7.
    Whalley, W. G., 1975, The Golgi Apparatus, Volume 2, Springer, Vienna.CrossRefGoogle Scholar
  8. 8.
    Schwartz, J. H., 1979, Annu. Rev. Neuroscl 2:467–504.CrossRefGoogle Scholar
  9. 9.
    Grafstein, B., and Forman, D. S., 1980, Physiol Rev. 60:1167–1283.PubMedGoogle Scholar
  10. 10.
    Thoenen, H., and Kreutzberg, G. W. (eds.), 1981, Neuroscl Res. Prog. Bull. 20:1–138.Google Scholar
  11. 11.
    Peters, A., Palay, S. L., and Webster, H. F., 1976, The Fine Structure of the Nervous System, Saunders, Philadelphia.Google Scholar
  12. 12.
    Palay, S. L., and Chan-Palay, V., 1977, Handbook of Physiology (E. R. Kandel, ed.), American Physiological Society, Bethesda, pp. 5–37.Google Scholar
  13. 13.
    Thiery, G., and Rambourg, A., 1976, J. Microsc. Biol. Cell 26:103–106.Google Scholar
  14. 14.
    Tsukita, S., and Ishikawa, H., 1976, J. Electron Microsc. 25:141–149.Google Scholar
  15. 15.
    Droz, B., Rambourg, A., and Koenig, H. L., 1975, Brain Res. 92:1–13.CrossRefGoogle Scholar
  16. 16.
    Alonso, G., and Assenmacher, I., 1978, Biol. Cell 32:205–208.Google Scholar
  17. 17.
    Palay, S. L., 1958, Exp. Cell Res. [Suppl.] 5:275–293.Google Scholar
  18. 18.
    Beaudet, A., and Rambourg, A., 1979, Biol. Cell 35:14a.Google Scholar
  19. 19.
    Kreutzberg, G. W., and Gross, G. W., 1977, Cell. Tissue Res. 181:443–457.PubMedCrossRefGoogle Scholar
  20. 20.
    Porter, K. R., Byers, H. R., and Ellisman, M. H., 1979, The Neurosciences, 4th Study Pro-gram (F. O. Schmitt and F. G. Worden, eds.), MIT Press, Cambridge, Massachusetts, pp. 703–722.Google Scholar
  21. 21.
    Alonso, G., and Assenmacher, I., 1979, Cell. Tissue Res. 189:415–429.Google Scholar
  22. 22.
    Rosenbluth, J., 1962, J. Cell Biol. 13:207–217.CrossRefGoogle Scholar
  23. 23.
    Palay, S. L., and Chan-Palay, V., 1973, Metabolic Compartimentation in the Brain (R. Bálazs and J. E. Cremer, eds.), Macmillan, London, pp. 187–207.Google Scholar
  24. 24.
    Reiter, W., 1966, Z. Zellforsch. Mikrosk. Anat. 72:446–461.PubMedCrossRefGoogle Scholar
  25. 25.
    Spacek, J., and Lieberman, A. R., 1980, J. Cell. Sci. 46:129–147.PubMedGoogle Scholar
  26. 26.
    Holtsman, E., Teichberg, S., Abrahams, S. J., Citkowitz, E., Crain, S. M., Kawai, N., and Peterson, E. R., 1972, J. Histochem. Cytochem. 21:349–385.CrossRefGoogle Scholar
  27. 27.
    Teichberg, S., and Holtzman, E., 1973, J. Cell Biol. 57:88–108.PubMedCrossRefGoogle Scholar
  28. 28.
    Dellman, H. D., Castel, M., and Linner, J. G., 1978, Gen. Comp. Endocrinol. 36:477–486.CrossRefGoogle Scholar
  29. 29.
    Robertson, J. D., 1970, The Neurosciences Second Study Program (F. O. Schmidt, ed.), Rockefeller University Press, New York, pp. 715–728.Google Scholar
  30. 30.
    Korneliussen, H., 1972, Z. Zeilforsch. 130:28–57.CrossRefGoogle Scholar
  31. 31.
    Heraandez-Nicaise, M. C., 1973, J. Neurocytol. 2:249–263.CrossRefGoogle Scholar
  32. 32.
    Taxi, J., and Sotelo, C., 1973, Brain Res. 62:431–437.PubMedCrossRefGoogle Scholar
  33. 33.
    Couteaux, R., 1974, Advances in Cytopharmacology, Volume 2 (B. Ceccarelli, F. Clementi, and J. Meldolesi, eds.), Raven Press, New York, pp. 369–379.Google Scholar
  34. 34.
    Markov, D., Rambourg, A., and Droz, B., 1976, J. Microsc. Biol. Cell. 25:57–60.Google Scholar
  35. 36.
    Lebeux, Y. J., and Willemot, J., 1975, Cell. Tissue Res. 160:1–36.PubMedGoogle Scholar
  36. 37.
    Alonso, G., Gaboon, J., Travers, E., and Assenmacher, I., 1981, Cell. Tissue Res. 214:323–341.PubMedCrossRefGoogle Scholar
  37. 38.
    Tytell, M., Black, M. M., Garner, J. A., and Lasek, R. J., 1981, Science 214:179–181.PubMedCrossRefGoogle Scholar
  38. 39.
    Pellegrino de Iraldi, A., and De Rogriguez, E., 1968, Z. Zellforsch. 87:330–344.CrossRefGoogle Scholar
  39. 40.
    Kapeller, K., and Mayor, D., 1979, Proc. R. Soc. (Lond.) [Biol.] 172:39–51.CrossRefGoogle Scholar
  40. 41.
    Smith, R. S., 1980, J. Neurocytol. 9:39–65.PubMedCrossRefGoogle Scholar
  41. 42.
    Tsukita, S., and Ishikawa, H., 1980, J. Cell Biol. 107:315–395.Google Scholar
  42. 43.
    Rambourg, A., and Droz, B., 1980, J. Neurochem. 35:16–25.PubMedCrossRefGoogle Scholar
  43. 44.
    Schonbach, J., Schonbach, C., and Cuenod, M., 1971, J. Comp. Neurol. 141:485–498.PubMedCrossRefGoogle Scholar
  44. 45.
    Droz, B., Koenig, H. L., Di Giamberardino, L., Couraud, J. Y., Chretien, M., and Souyri, F., 1979, Progress in Brain Research, Volume 49 (S. Tucek, ed.), Elsevier, Amsterdam, New York, pp. 23–44.Google Scholar
  45. 46.
    Hendrickson, A. E., 1972, J. Comp. Neurol. 144:381–397.CrossRefGoogle Scholar
  46. 47.
    Thompson, E. B., Schwartz, J. H., and Kandel, E. R., 1976, Brain Res. 112:251–281.PubMedCrossRefGoogle Scholar
  47. 48.
    Ellisman, M. H., and Lindsey, J. D., 1981, J. Cell Biol. 91:91a.Google Scholar
  48. 49.
    Sotelo, C., and Riche, D., 1974, Anat. Embryol. 146:209–218.PubMedCrossRefGoogle Scholar
  49. 50.
    Nauta, H. J. W., Kaiserman-Ambramof, I. R., and Lasek, R. J., 1975, Brain Res. 85:373–384.PubMedCrossRefGoogle Scholar
  50. 51.
    Schwab, M., and Thoenen, H., 1977, Brain Res. 122:459–474.PubMedCrossRefGoogle Scholar
  51. 52.
    Lasek, R. J., and Hoffman, P. N., 1976, Cell Motility, Volume 3 (R. Goldman, J. Pollard, and J. Rosenbaum, eds.), Cold Spring Harbor Laboratory, New York, pp. 1021–1049.Google Scholar
  52. 53.
    Dolivo, M., Beretta, E., Bonifas, F., and Foroglou, C., 1978, Brain Res. 140:111–123.PubMedCrossRefGoogle Scholar
  53. 54.
    LaVail, J. H., Rapisardi, S., and Sugino, I. K., 1980, Brain Res. 121:3–20.CrossRefGoogle Scholar
  54. 55.
    Breuer, A. C., Christian, C. N., Henlart, M., and Nelson, P. G., 1975, J. Cell. Biol. 65:562–576.PubMedCrossRefGoogle Scholar
  55. 56.
    Grafstein, B. J., Miller, J. A., Ledeen, R. W., Haley, J., and Specht, S. C., 1975, Exp. Neurol. 46:261–281.PubMedCrossRefGoogle Scholar
  56. 57.
    Rostas, J. A. P., Austin, L., and Jeaffrey, P. L., 1979, J. Neurochem. 32:1461–1466.PubMedCrossRefGoogle Scholar
  57. 58.
    Abe, T., Haga, T., and Kurokawa, M., 1973, Biochem. J. 136:731–740.PubMedGoogle Scholar
  58. 59.
    Holtzman, E., and Mercurio, A. M., 1980, Int. Rev. Cytol. 67:1–67.PubMedCrossRefGoogle Scholar
  59. 60.
    Stelzner, D. J., 1971, Z. Zeilforsch. 120:332–335.CrossRefGoogle Scholar
  60. 61.
    Lane, N. J., and Swales, L. S., 1976, J. Cell Sci. 22:435–453.PubMedGoogle Scholar
  61. 62.
    Reinecke, M., and Walther, C., 1968, J. Cell Biol. 78:839–855.CrossRefGoogle Scholar
  62. 63.
    Brzin, M. V., Tennuson, M., and Duffy, P. E., 1966, J. Cell Biol. 31:215–242.PubMedCrossRefGoogle Scholar
  63. 64.
    Kaza, P., Mann, S. P., Karsch, S., Toth, L., and Jordan, S., 1973, J. Neurochem. 21:431–436.CrossRefGoogle Scholar
  64. 65.
    Cimarusti, D. L., Saito, K., Vaughn, J. E., Baker, R., Roberts, E., and Thomas, R. E., 1979, Brain Res. 162:55–67.PubMedCrossRefGoogle Scholar
  65. 66.
    Holtzman, E., 1977, Neuroscience 2:327–355.PubMedCrossRefGoogle Scholar
  66. 67.
    Broadwell, R. E., 1980, J. Histochem. Cytochem. 28:87–89.PubMedCrossRefGoogle Scholar
  67. 68.
    Whitaker, S., and Labella, F. S., 1972, Z. Zeilforsch. 125:1–15.CrossRefGoogle Scholar
  68. 69.
    Boudier, J. A., Marchi, D., Cataldo, C., Massacrier, A., and Cau, P., 1981, Biol. Cell. 40:33–40.Google Scholar
  69. 70.
    Sachs, H., 1970, Handbook of Neurochemistry, Volume 4 (A. Lajtha, ed.), Plenum Press, New York, pp. 373–428.Google Scholar
  70. 71.
    Mason, C. A., and Bern, H. A., 1977, Handbook of Physiology, Volume I (E. R. Kandel, ed.), American Physiological Society, Bethesda, pp. 651–689.Google Scholar
  71. 72.
    Palay, S. L., 1957, Ultrastructure and Cellular Chemistry of Neural Tissue (H. Waelsch, ed.), Cassels, London, pp. 31–49.Google Scholar
  72. 73.
    Dellman, H. D., and Rodriguez, E. M., 1970, Experientia 26:414–415.CrossRefGoogle Scholar
  73. 74.
    Norstrom, A., 1971, Brain Res. 28:131–142.PubMedCrossRefGoogle Scholar
  74. 75.
    Norstrom, A., and Sjostrand, J., 1972, J. Endocrinol. 52:87–105.PubMedCrossRefGoogle Scholar
  75. 76.
    Rougon-Rappuzzi, G., Cau, P., Boudier, J. A., and Cupo, A., 1978, Neuroendocrinology 27:46–62.CrossRefGoogle Scholar
  76. 77.
    Alonso, G., Gabrion, J., Lutz, B., and Assenmacher, I., 1980, J. Physiol.(Paris) 76:1b.Google Scholar
  77. 78.
    Krisch, B., 1980, J. Histochem. Cytochem. 28:472–474.PubMedCrossRefGoogle Scholar
  78. 79.
    Dreyfuss, F., Burlet, A., Chateau, M., and Czernichow, P., 1979, Biol. Cell. 35:141–164.Google Scholar
  79. 80.
    Quatacker, J., 1981, Histochem. J. 13:109–124.PubMedCrossRefGoogle Scholar
  80. 81.
    Tranzer, J. P., 1972, Nature 237:57–58.Google Scholar
  81. 82.
    Hammerschlag, R., Dravid, A. R., and Chiu, A. Y., 1975, Science 188:273–275.PubMedCrossRefGoogle Scholar
  82. 83.
    Blaustein, M. P., Ratzlaff, R. W., Kendrick, N. C., and Schweitzer, E. S., 1978, J. Gen. Physiol. 72:15–41.PubMedCrossRefGoogle Scholar
  83. 84.
    Duce, I. R., and Keen, P., 1978, Neuroscience 3:837–848.PubMedCrossRefGoogle Scholar
  84. 85.
    Henkart, M. P., Reese, T. S., and Brinley, F. J., 1978, Science 202:1300–1303.PubMedCrossRefGoogle Scholar
  85. 86.
    Iqbal, Z., and Ochs, S., 1978, J. Neurochem. 31:409–418.PubMedCrossRefGoogle Scholar
  86. 87.
    Blitz, A. L., Fine, R. E., and Toselli, P. A., 1977, J. Cell Biol. 75:135–147.PubMedCrossRefGoogle Scholar
  87. 88.
    Shaw, F. D., and Morris, J. F., 1980, Nature 287:56–58.PubMedCrossRefGoogle Scholar
  88. 89.
    Svardal, A. M., and Pryme, I. F., 1980, Sub. Biochem. 7:117–170.CrossRefGoogle Scholar
  89. 90.
    Tartakoff, A., and Vassalli, I. P., J. Cell Biol. 79:694–707.Google Scholar
  90. 91.
    Hammerschlag, R., and Stone, G., 1982, Axoplasmic Transport (D. G. Weiss, ed.), Springer-Verlag, Berlin, Heidelberg, New York, pp. 406–413.Google Scholar
  91. 92.
    Cardell, R. R., 1977, Int. Rev. Cytol. 48:221–279.PubMedCrossRefGoogle Scholar
  92. 93.
    Puszkin, S., and Schook, W., 1979, Methods and Achievements in Experimental Pathology, Volume 9 (G. Jasmin and M. Cantin, eds.), S. Karger, Basel, pp. 87–111.Google Scholar
  93. 94.
    Alonso, G., and Arancibia, S., (to be published).Google Scholar
  94. 95.
    Ochs, S., 1982, Science 176:252–260.CrossRefGoogle Scholar
  95. 96.
    David, A. R., and Hammerschlag, R., 1975, J. Neurochem. 24:711–718.Google Scholar
  96. 97.
    Droz, B., 1975, The Nervous System, Volume 1 (D. B. Tower, ed.), Raven Press, New York, pp. 111–127.Google Scholar
  97. 98.
    Sharp, G. A., Fritzsimons, J. T. R., and Kerkut, G. A., 1980, Comp. Biochem. Physiol. 66A:415–429.CrossRefGoogle Scholar
  98. 99.
    Lindsey, J. D., Hammerschlag, R., and Ellisman, M. H., 1981, Brain Res. 205:275–287.PubMedCrossRefGoogle Scholar
  99. 100.
    Stephens, H. R., and Sandbrown, E. B., 1976, Brain Res. 113:127–132.PubMedCrossRefGoogle Scholar
  100. 101.
    Gisiger, V., Venkov, L., and Gautron, J., 1975, J. Neurochem. 25:737–748.PubMedCrossRefGoogle Scholar
  101. 102.
    Somogyi, P., and Chubb, I. W., 1976, Neuroscience 1:413–421.PubMedCrossRefGoogle Scholar
  102. 103.
    Griffith, D. L., and Bondareef, 1973, Am. J. Anat. 136:549–556.PubMedCrossRefGoogle Scholar
  103. 104.
    Csillik, B., Knyihar, E., Laszlo, I., and Boncz, I., 1974, Brain Res. 70:179–183.PubMedCrossRefGoogle Scholar
  104. 105.
    Castel, M., and Dellman, H. D., 1980, Cell Tissue Res. 210:205–221.PubMedCrossRefGoogle Scholar
  105. 106.
    Broadwell, R. D., and Oliver, C., 1981, J. Cell Biol. 90:474–484.PubMedCrossRefGoogle Scholar
  106. 107.
    Novikoff, A. B., Mori, M., Quintana, N., and Hauw, J. J., 1971, J. Cell Biol. 50:859–886.PubMedCrossRefGoogle Scholar
  107. 108.
    Novikoff, A. B., 1967, The Neuron (H. Hyden, ed.), Elsevier, Amsterdam, pp. 255–318.Google Scholar
  108. 109.
    Kreutzberg, G. W., Schubert, P., Toth, L., and Rieske, E., 1973, Brain Res. 62:399–404.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Gérard Alonso
    • 1
  1. 1.Laboratoire de NeuroendocrinologieUniversité de Montpellier IIMontpellierFrance

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