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Noradrenergic Vesicles

Molecular Organization and Function
  • Richard L. Klein
  • Åsa K. Thureson-Klein

Abstract

Morphological and biochemical evidence supports the concept that large dense-cored vesicles (LDVs, 75–90 nm diameter) originate exclusively in the perikaryon, where their membranes are synthesized and they are packaged with specific membrane and matrix components except for norepinephrine (NE). Thus, LDVs can be found along the nerve axons as they are transported toward and accumulated in the terminals of all peripheral noradrenergic nerves (Fig. 1). It follows that the yield of LDVs in isolated fractions will be greater per nerve weight in the proximal to distal direction, and this can be demonstrated experimentally by taking sequential segments of the nerve for vesicle isolation (Section 3.1).

Keywords

Opioid Peptide Chromaffin Granule Axoplasmic Transport Exocytotic Release Total Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Richard L. Klein
    • 1
  • Åsa K. Thureson-Klein
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Mississippi Medical CenterJacksonUSA

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