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The Blood-Brain Barrier

  • William H. Oldendorf

Abstract

The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored. In general, it is the extracellular fluid (ECF) to which such dyes distribute to color the tissues. The blood plasma is a rapidly circulating subcompartment serving to disperse any local concentration of solute throughout the entire ECF. It can carry out this homogenizing function because of the ubiquity and permeability of capillaries. These capillary characteristics, together with the movement of blood plasma, bring the effective distances that solutes are required to diffuse between various body cells down to a few micrometers.

Keywords

Monocarboxylic Acid Mitochondrial Content Tritiated Water Arachnoid Membrane Brain Capillary Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • William H. Oldendorf
    • 1
    • 2
    • 3
  1. 1.VA Medical CenterLos AngelesUSA
  2. 2.Departments of Neurology and PsychiatryUniversity of CaliforniaLos AngelesUSA
  3. 3.School of MedicineLos AngelesUSA

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