Brain Capillaries

Structure and Function
  • A. Lords Betz
  • Gary W. Goldstein


It is now well accepted that the brain capillary is the structure responsible for the formation of a blood-brain barrier (BBB). However, brain capillaries are also involved in a number of other metabolic and transport processes that may be equally important for brain function. The study of these biochemical properties was furthered by the development of methods to isolate metabolically active microvessels from brain.1–6 This technical advance permitted investigation of capillary properties not accessible to study in vivo. As a result, many new ideas concerning brain capillary function were proposed during the past decade. In this chapter we review the structure and function of the brain capillary and attempt to integrate newer biochemical findings with the traditional concept of the BBB.


Basement Membrane Tight Junction Capillary Endothelial Cell Brain Capillary Brain Microvessels 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Lords Betz
    • 1
  • Gary W. Goldstein
    • 1
  1. 1.Departments of Pediatrics and NeurologyUniversity of MichiganAnn ArborUSA

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