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The Axonal Plasma Membrane

  • George H. DeVries

Abstract

The organelles and cytoplasm within the axonal process are enclosed by a plasma membrane known as the axonal plasma membrane or axolemma. This membrane may be defined as the surface membrane of the axonal process from the point at which it emerges from the axon hillock of the neuronal perikaryon to the axonal terminal or nerve ending, which forms a synapse on another cell.1 The axonal plasma membrane may or may not be ensheathed by myelin synthesized by the Oligodendroglia (CNS) or Schwann cells (PNS). The axonal plasma membrane is characterized by functional molecular heterogeneity. Therefore, when dealing with this membrane, one must define the state of myelination of the axonal plasma membrane in question and, if myelinated, state the localization of the membrane within the myelinated axon (internodal or nodal).

Keywords

Schwann Cell Sodium Channel Myelinated Axon Axonal Membrane Unmyelinated Axon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Peters, A., Palay, S. L., and Webster, H. de F., 1976, The Fine Structure of the Nervous System, W. B. Saunders, Philadelphia, p. 106.Google Scholar
  2. 2.
    Camejo, G., Villegas, G., Barnola, F., and Villegas, R., 1969, Biochim. Biophys. Acta 193:247–259.CrossRefPubMedGoogle Scholar
  3. 3.
    Fischer, S., Cellino, M., Zambrano, F., Zampighi, G., Tellez-Nagel, M., Marcus, D., and Canessa-Fischer, M., 1970, Arch. Biochem. Biophys. 138:1–15.CrossRefPubMedGoogle Scholar
  4. 4.
    Denburg, J. L., 1972, Biochim. Biophys. Acta 282:453–458.CrossRefPubMedGoogle Scholar
  5. 5.
    Chacko, G. K., Goldman, D. E., Malhotra, H. C., and Dewey, M. M., 1974, J. Cell Biol. 62:831–843.CrossRefPubMedGoogle Scholar
  6. 6.
    Balerna, M., Fosset, M., Chicheportiche, R., Romey, G., and Lazdunski, M., 1975, Biochemistry 14:5500–5511.CrossRefPubMedGoogle Scholar
  7. 7.
    DeVries, G. H., 1981, Research Methods in Neurochemistry, Volume 5 (W. Marks and R. Rodnight, eds.), Plenum Press, New York, pp. 3–38.Google Scholar
  8. 8.
    Yoshino, J. E., Griffin, J. W., and DeVries, G. H., 1983, J. Neurochem. 41:1126–1130.CrossRefPubMedGoogle Scholar
  9. 9.
    Yoshino, J. E., and DeVries, G. H., 1983, Trans. Amer. Soc. Neurochem. 14:111.Google Scholar
  10. 10.
    Salzer, J. L., Williams, A. K., Glaser, L., and Bunge, R. P., 1980, J. Cell Biol. 84:753–766.CrossRefPubMedGoogle Scholar
  11. 11.
    Easton, D. M., 1971, Science 172:952–955.CrossRefPubMedGoogle Scholar
  12. 12.
    Steinbrecht, R. A., 1969, J. Cell Sci. 4:39–53.PubMedGoogle Scholar
  13. 13.
    DeVries, G. H., Anderson, M. G., and Johnson, D. L., 1983, J. Neurochem. 40:1709–1717.CrossRefPubMedGoogle Scholar
  14. 14.
    DeVries, G. H., and Lazdunski, M., 1982, J. Biol. Chem. 257:11684–11688.PubMedGoogle Scholar
  15. 15.
    Rulfs, J., and DeVries, G. H., 1982, Trans. Amer. Soc. Neurochem. 13:173.Google Scholar
  16. 16.
    DeVries, G. H., Matthieu, J.-M., Beny, M., Chicheportiche, R., Lazdunski, M., and Dolivo, M., 1978, Brain Res. 147:339–352.CrossRefPubMedGoogle Scholar
  17. 17.
    DeVries, G. H., 1976, Neurosci. Lett. 3:117–122.CrossRefGoogle Scholar
  18. 18.
    Zetusky, W., Calabrese, V. P., Zetusky, A., Anderson, M. G., Cullen, M., and DeVries, G. H., 1979, J. Neurochem. 32:1103–1109.CrossRefPubMedGoogle Scholar
  19. 19.
    Barnola, F., Villegas, R., and Camejo, G., 1973, Biochim. Biophys. Acta 298:84–94.CrossRefPubMedGoogle Scholar
  20. 20.
    Chacko, G., Villegas, G., Barnola, F., Villegas, R and Goldman, D., 1976, Biochim. Biophys. Acta 443:19–32.CrossRefPubMedGoogle Scholar
  21. 21.
    Wood, J. G., Jean, D. H., Whitaker, J. N., McLaughlin, B. J., and Albers, R. W., 1977, J. Neurocytol. 6:571–581.CrossRefPubMedGoogle Scholar
  22. 22.
    Schwartz, M., Ernst, S. A., Siegel, G. A., and Agranoff, B. W., 1981, J. Neurochem. 36:107–115.CrossRefPubMedGoogle Scholar
  23. 23.
    Sweadner, K., 1979, J. Biol. Chem. 254:6060–6067.PubMedGoogle Scholar
  24. 24.
    Kracke, G. R., and Chacko, G. K., 1979, Life Sci. 25:2125–2129.CrossRefPubMedGoogle Scholar
  25. 25.
    Gache, C., Rossi, B., and Lazdunski, M., 1976, Eur. J. Biochem. 65:293–306.CrossRefPubMedGoogle Scholar
  26. 26.
    Rossi, B., Gache, C., and Lazdunski, M., 1978, Eur. J. Biochem. 85:561–570.CrossRefPubMedGoogle Scholar
  27. 27.
    Stanley, J., Saul, R. G., Hadfield, M. G., and DeVries, G. H., 1979, Neuroscience 4:155–167.CrossRefPubMedGoogle Scholar
  28. 28.
    Nachmansohn, D., and Newman, E., 1975, Chemical and Electrical Basis of Nerve Activity, Academic Press, New York, pp. 253–259.Google Scholar
  29. 29.
    Sabatini, M., Dipolo, R., and Villegas, R., 1968, J. Cell Biol. 38:176–183.CrossRefPubMedGoogle Scholar
  30. 30.
    Cecchi, X., Canessa-Fischer, M., Maturana, A., and Fischer, S., 1971, Arch. Biochem. Biophys. 145:240–247.CrossRefGoogle Scholar
  31. 31.
    Benes, F., Higgins, J. A., and Barnett, R., 1973, J. Cell Biol. 57:613–629.CrossRefPubMedGoogle Scholar
  32. 32.
    Estridge, M., and Bunge, R., 1978, J. Cell Biol. 79:138–155.CrossRefPubMedGoogle Scholar
  33. 33.
    Harford, J. B., Waechter, C. J., Saul, R., and DeVries, G. H., 1979, J. Neurochem. 32:91–98.CrossRefPubMedGoogle Scholar
  34. 34.
    Costantino-Ceccarini, E., Cestelli, A., and DeVries, G. H., 1979, J. Neurochem. 32:1175–1182.CrossRefPubMedGoogle Scholar
  35. 35.
    DeVries, G. H., Chalifour, R. J., and Kanfer, J. N., 1983, J. Neurochem. 40:1189–1191.CrossRefPubMedGoogle Scholar
  36. 36.
    Stahl, W. L., 1973, Arch. Biochem. Biophys. 154:56–65.CrossRefPubMedGoogle Scholar
  37. 37.
    Chacko, G., 1979, J. Membr. Biol. 47:285–301.CrossRefPubMedGoogle Scholar
  38. 38.
    Grefrath, S., and Reynolds, J. A., 1973, J. Biol. Chem. 248:6091–6094.PubMedGoogle Scholar
  39. 39.
    DeVries, G. H., Payne, W., and Saul, R. G., 1981, Neurochem. Res. 6:521–537.CrossRefPubMedGoogle Scholar
  40. 40.
    Estridge, M., 1977, Nature 268:60–63.CrossRefPubMedGoogle Scholar
  41. 41.
    Chang, C.-M., and Goldman, R. D., 1973, J. Cell Biol. 57:867–874.CrossRefPubMedGoogle Scholar
  42. 42.
    Goodrum, J. F., and Morell, P., 1982, J. Neurochem. 38:696–704.CrossRefPubMedGoogle Scholar
  43. 43.
    Chacko, G. K., Barnola, F. V., Villegas, R., and Goldman, D. E., 1974, Biochim. Biophys. Acta 373:308–312.CrossRefPubMedGoogle Scholar
  44. 44.
    Ritchie, J. M., and Rogart, R. B., 1977, Proc. Natl. Acad. Sci. U.S.A. 74:211–215.CrossRefPubMedGoogle Scholar
  45. 45.
    Chiu, S. Y., and Ritchie, J. M., 1980, Nature 284:170–171.CrossRefPubMedGoogle Scholar
  46. 46.
    Catterall, W. A., 1980, Annu. Rev. Pharmacol. Toxicol. 20:15–43.CrossRefPubMedGoogle Scholar
  47. 47.
    Denburg, J. L., 1976, Life Sci. 18:751–758.CrossRefPubMedGoogle Scholar
  48. 48.
    Baumgold, J., 1980, J. Neurochem. 34:327–334.CrossRefPubMedGoogle Scholar
  49. 49.
    Rhoden, V. A., and Goldin, S. M., 1979, J. Biol. Chem. 254:11199–11201.PubMedGoogle Scholar
  50. 50.
    Vincent, J. P., Balerna, M., Barhanin, J., Fosset, M., and Lazdunski, M., 1980, Proc. Natl. Acad. Sci. U.S.A. 77:1646–1650.CrossRefPubMedGoogle Scholar
  51. 51.
    Catterall, W. A., Morrow, C. S., and Hartshorne, R. P., 1979, J. Biol. Chem. 254:11379–11387.PubMedGoogle Scholar
  52. 52.
    Denburg, J. L., Eldefrawi, M. E., and O’Brien, R. D., 1972, Proc. Natl. Acad. Sci. U.S.A. 69:177–181.CrossRefPubMedGoogle Scholar
  53. 53.
    Chester, J., Lentz, T. L., Marguis, J. K., and Mautner, H., 1979, Proc. Natl. Acad. Sci. U.S.A. 76:3542–3546.CrossRefPubMedGoogle Scholar
  54. 54.
    Jumblatt, J. E., Marguis, J. K., and Mautner, H., 1981, J. Neurochem. 37:392–400.CrossRefPubMedGoogle Scholar
  55. 55.
    DeVries, G. H., Zetusky, W. J., Zmachinski, C. J., and Calabrese, V. P., 1981, J. Lipid Res. 22:208–216.PubMedGoogle Scholar
  56. 56.
    DeVries, G. H., and Zmachinski, C. J., 1980, J. Neurochem. 34:424–430.CrossRefGoogle Scholar
  57. 57.
    Chacko, G. K., Barnola, F. V., and Villegas, R., 1977, J. Neurochem. 28:445–447.CrossRefPubMedGoogle Scholar
  58. 58.
    Zambrano, F., Cellino, M., and Canessa-Fischer, M., 1971, J. Membr. Biol. 6:289–303.CrossRefGoogle Scholar
  59. 59.
    Cotman, C., Blank, L. M., Moehl, A., and Snyder, F., 1969, Biochemistry 11:4606–4612.CrossRefGoogle Scholar
  60. 60.
    Houslay, M. D., and Stanley, K. K., 1982, Dynamics of Biological Membranes, John Wiley & Sons, New York, p. 20.Google Scholar
  61. 61.
    De Gier, J., Mandershool, J. G., and Van Deenen, L. L. M., 1968, Biochim. Biophys. Acta 150:666–685.CrossRefPubMedGoogle Scholar
  62. 62.
    Haley, J. E., and Ledeen, R. W., 1979, J. Neurochem. 32:735–742.CrossRefPubMedGoogle Scholar
  63. 63.
    Norton, W. T., Abe, T., Poduslo, S., and DeVries, G. H., 1975, J. Neurosci. Res. 1:57–75.CrossRefPubMedGoogle Scholar
  64. 64.
    Norton, W. T., and Autilio, L. A., 1966, J. Neurochem. 13:213–222.CrossRefPubMedGoogle Scholar
  65. 65.
    DeVries, G. H., and Norton, W. T., 1974, J. Neurochem. 22:259–264.CrossRefPubMedGoogle Scholar
  66. 66.
    DeVries, G. H., and Norton, W. T., 1974, J. Neurochem. 22:251–257.CrossRefPubMedGoogle Scholar
  67. 67.
    Shook, W., and Norton, W. T., 1976, Brain Res. 118:517–522.CrossRefGoogle Scholar
  68. 68.
    Henderson, T. J., Bigbee, J. W., and DeVries, G. H., 1984, Brain Res. (in press).Google Scholar
  69. 69.
    Breckenridge, W. C., Gombos, G., and Morgan, I., 1972, Biochim. Biophys. Acta 266:695–707.CrossRefPubMedGoogle Scholar
  70. 70.
    Kriegler, J. S., Krishman, N., and Singer, M., 1981, Adv. Neurol. 31:479–504.PubMedGoogle Scholar
  71. 71.
    Zambrano, F., Morales, M., Fuentes, N., and Rojas, M., 1981, J. Membr. Biol. 63:71–75.CrossRefPubMedGoogle Scholar
  72. 72.
    Ganser, A., Kirchner, D., and Willinger, M., 1983, J. Neurocytol. 12:921–938.CrossRefPubMedGoogle Scholar
  73. 73.
    Foster, R. E., Whalen, C. C., and Waxman, S. G., 1980, Science 210:661–663.CrossRefPubMedGoogle Scholar
  74. 74.
    Smith, K. J., Bostock, H., and Hall, S. M., 1982, J. Neurol. Sci. 54:13–31.CrossRefPubMedGoogle Scholar
  75. 75.
    DeVries, G. H., Salzer, J. L., and Bunge, R. P., 1982, Dev. Brain Res. 3:295–299.CrossRefGoogle Scholar
  76. 76.
    DeVries, G. H., Minier, L., and Lewis, B. L., 1983, Dev. Brain Res. 9:87–93.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • George H. DeVries
    • 1
  1. 1.Department of BiochemistryMedical College of VirginiaRichmondUSA

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