Brain Slices pp 155-199 | Cite as


Electrophysiological Studies of Epileptiform Activity in Vitro
  • Bradley E. Alger


Studies on epileptic phenomena have multiplied rapidly with the growing realization that many of the persistent problems in the field can be attacked directly using the in vitro slice preparation. Recently, the hip-pocampal slice has been most widely used in studies of epilepsy for reasons that are detailed in the Appendix. While attempting to present an overview of electrophysiological studies of epilepsy in the hippo-campal slice, this review will focus on data that has appeared since 1978. The fundamental hypothesis concerning the intrinsic nature of the epileptiform “burst” potential has been widely supported (see Prince, 1978; Schwartzkroin and Wyler, 1980). The chief areas of departure of the present discussion from previous reviews will be in consideration of data pertaining to: (1) the existence of “giant excitatory postsynaptic potentials (EPSPs),” (2) modes of inhibitory synaptic control over pyramidal cell dendrites, (3) the nature of various afterhyperpolarizations, (4) ways in which synchronization of firing within a neuronal population can occur, and (5) mechanisms that can enable epileptic discharges to spread.


Pyramidal Cell Hippocampal Slice Epileptiform Activity Hippocampal Pyramidal Cell Interictal Spike 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Bradley E. Alger
    • 1
  1. 1.Department of PhysiologyUniversity of Maryland School of MedicineBaltimoreUSA

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